Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases

IF 7.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Free Radical Biology and Medicine Pub Date : 2024-10-16 DOI:10.1016/j.freeradbiomed.2024.10.269

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Abstract

With the development of the technology to generate transgenic and knockout mice in the 1990s, investigators had a powerful tool to directly test the impact of altering a specific gene on a biological process or disease. Over the past three decades, investigators have used transgenic and knockout mouse models, which have altered expression of antioxidant genes, to test the role of oxidative stress/damage in aging and age-related diseases. In this comprehensive review, we describe the studies using transgenic and knockout mouse models to test the role of oxidative stress/damage in aging (longevity) and three age-related diseases, e.g., sarcopenia, cardiac aging, and Alzheimer's Disease. While longevity was consistently altered only by one transgenic and one knockout mouse model as predicted by the Oxidative Stress Theory of Aging, the incidence/progression of the three age-related diseases (especially Alzheimer's disease) were robustly impacted when the expression of various antioxidant genes was altered using transgenic and knockout mouse models.

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用于测试活性氧在衰老和与年龄相关的慢性疾病中的作用的小鼠模型。

随着 20 世纪 90 年代转基因小鼠和基因敲除小鼠技术的发展，研究人员拥有了一种强大的工具，可以直接测试改变特定基因对生物过程或疾病的影响。在过去的三十年中，研究人员利用改变了抗氧化基因表达的转基因和基因敲除小鼠模型来测试氧化应激/损伤在衰老和老年相关疾病中的作用。在这篇综述中，我们介绍了利用转基因和基因敲除小鼠模型测试氧化应激/损伤在衰老（长寿）和三种与年龄相关疾病（如肌肉疏松症、心脏衰老和阿尔茨海默病）中的作用的研究。正如氧化应激衰老理论所预测的那样，只有一种转基因小鼠和一种基因敲除小鼠模型会持续改变寿命，而当使用转基因和基因敲除小鼠模型改变各种抗氧化基因的表达时，三种与年龄有关的疾病（尤其是阿尔茨海默病）的发病率/进展会受到强烈影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Free Radical Biology and Medicine 医学-内分泌学与代谢

CiteScore

14.00

自引率

4.10%

发文量

850

审稿时长

22 days

期刊介绍： Free Radical Biology and Medicine is a leading journal in the field of redox biology, which is the study of the role of reactive oxygen species (ROS) and other oxidizing agents in biological systems. The journal serves as a premier forum for publishing innovative and groundbreaking research that explores the redox biology of health and disease, covering a wide range of topics and disciplines. Free Radical Biology and Medicine also commissions Special Issues that highlight recent advances in both basic and clinical research, with a particular emphasis on the mechanisms underlying altered metabolism and redox signaling. These Special Issues aim to provide a focused platform for the latest research in the field, fostering collaboration and knowledge exchange among researchers and clinicians.