Progress in the regulatory mechanism of mitophagy in chronic cerebral ischemic neuronal injury

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-10-16 DOI:10.1016/j.expneurol.2024.115003

Lihong Li , Rui Yuan , Moxin Wu , Xiaoping Yin , Manqing Zhang , Zhiying Chen

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Abstract

Chronic cerebral ischemia (CCI) is a common clinical syndrome that can impact various cerebrovascular diseases. Its pathological mechanism of injury involves energy imbalance, oxidative stress, inflammatory response, and many other processes. Neuronal damage occurs in a complex and multifaceted manner. This article provides a detailed discussion of the activation and inhibition mechanisms of mitophagy under cerebral ischemia and considers the advantages and disadvantages of mitophagy in the recovery process of ischemic brain injury. Finally, we address the future direction of research on neuronal injury and the regulatory mechanisms of mitophagy in chronic cerebral ischemia. Future studies should focus on drug intervention at specific regulatory points and the cross-regulation of related signaling pathways to comprehensively deepen understanding of the mechanisms of neuronal injury in chronic cerebral ischemia. Promising interventions could potentially improve the treatment and outcomes of chronic cerebral ischemia.

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慢性脑缺血神经元损伤中有丝分裂调控机制的研究进展

慢性脑缺血（CCI）是一种常见的临床综合征，可影响多种脑血管疾病。其损伤的病理机制涉及能量失衡、氧化应激、炎症反应和许多其他过程。神经元损伤的发生是复杂而多方面的。本文详细讨论了脑缺血情况下有丝分裂的激活和抑制机制，并探讨了有丝分裂在缺血性脑损伤恢复过程中的利弊。最后，我们探讨了慢性脑缺血中神经元损伤和有丝分裂调控机制的未来研究方向。未来的研究应关注特定调控点的药物干预以及相关信号通路的交叉调控，以全面加深对慢性脑缺血神经元损伤机制的认识。有希望的干预措施有可能改善慢性脑缺血的治疗和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.