The interplay of dietary mycotoxins and oncogenic viruses toward human carcinogenesis: a scoping review.

IF 7.3 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Critical reviews in food science and nutrition Pub Date : 2024-10-18 DOI:10.1080/10408398.2024.2414828

Thanos Mouchtaris Michailidis, Sarah De Saeger, Rita Khoueiry, Grace A Odongo, Yasmine Bader, Maarten Dhaenens, Zdenko Herceg, Marthe De Boevre

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引用次数: 0

Abstract

Background: Mycotoxins, fungal metabolites prevalent in many foods, are recognized for their role in carcinogenesis, especially when interacting with oncogenic viruses.

Objectives: This scoping review synthesizes current evidence on the human cancer risk associated with mycotoxin exposure and oncogenic virus infections.

Methods: Searches were conducted on PubMed, Embase, and Web of Science. Studies were selected based on the PECOS framework. Data extraction involved narrative and qualitative presentation of findings, with meta-analysis where feasible. Risk of bias and outcome quality were assessed using the OHAT tool and GRADE approach.

Results: From 25 included studies, 18 focused on aflatoxins and hepatitis viruses in hepatocellular carcinoma (HCC). Four studies examined aflatoxin B1 (AFB1) and human papilloma virus (HPV) in cervical cancer, while three investigated AFB1 with Epstein-Barr virus (EBV) in lymphomagenesis. The review highlights a significant synergistic effect between AFB1 and hepatitis B and C viruses in HCC development. Significant interactions between AFB1 and HPV, as well as AFB1 and EBV, were observed, but further research is needed.

Conclusions: The synergistic impact of mycotoxins and oncogenic viruses is a critical public health concern. Future research, especially prospective cohort studies and investigations into molecular mechanisms, is essential to address this complex issue.

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膳食霉菌毒素和致癌病毒对人类致癌的相互作用：范围综述。

背景：霉菌毒素是许多食物中普遍存在的真菌代谢产物，其致癌作用已得到公认，尤其是在与致癌病毒相互作用时：本综述综述了与霉菌毒素暴露和致癌病毒感染相关的人类癌症风险的现有证据：方法：在 PubMed、Embase 和 Web of Science 上进行检索。根据 PECOS 框架选择研究。数据提取包括对研究结果的叙述和定性陈述，并在可行的情况下进行荟萃分析。采用 OHAT 工具和 GRADE 方法对偏倚风险和结果质量进行了评估：在纳入的 25 项研究中，有 18 项研究重点关注黄曲霉毒素和肝炎病毒在肝细胞癌（HCC）中的作用。四项研究探讨了黄曲霉毒素 B1（AFB1）和人乳头瘤病毒（HPV）在宫颈癌中的作用，三项研究探讨了黄曲霉毒素 B1 和 Epstein-Barr 病毒（EBV）在淋巴瘤中的作用。综述强调了 AFB1 与乙型肝炎病毒和丙型肝炎病毒在 HCC 发展过程中的显著协同效应。AFB1与HPV以及AFB1与EBV之间存在显著的相互作用，但仍需进一步研究：结论：霉菌毒素和致癌病毒的协同影响是一个重要的公共卫生问题。未来的研究，尤其是前瞻性队列研究和分子机制调查，对于解决这一复杂问题至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.