A comprehensive update on the immunoregulatory mechanisms of Akkermansia muciniphila: insights into active ingredients, metabolites, and nutrient-driven modulation.

IF 7.3 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Critical reviews in food science and nutrition Pub Date : 2024-10-16 DOI:10.1080/10408398.2024.2416481

Lihua Mei, Jiaxin Wang, Yanling Hao, Xiangfang Zeng, Ying Yang, Zhenlong Wu, Yun Ji

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引用次数: 0

Abstract

Akkermansia muciniphila (A. muciniphila) has gained recognition as a pioneering probiotic, exhibiting considerable potential to enhance immune conditions across both humans and animals. The health benefits of A. muciniphila are attributed to its various components, including outer membrane proteins (PilQ and Amuc_1100), secreted proteins (P9 and AmTARS), extracellular vesicles, and metabolites such as SCFAs, ornithine lipids, γ-aminobutyric acid, cobalamin, and inosine. The dynamic control of the mucus layer by A. muciniphila plays a crucial role in regulating intestinal mucosal immunity. Furthermore, A. muciniphila modulates immune function by interacting with macrophages, dendritic cells, T lymphocytes, and Paneth cells. Increasing the abundance of A. muciniphila in the gut through nutritional strategies represents a safe and effective means to augment immune function. Various polyphenols, oligosaccharides, and polysaccharides have been shown to elevate the levels of this bacterium, thereby contributing to favorable immunoregulatory outcomes. This paper delves into the latest research advancements related to the probiotic mechanisms of A. muciniphila and provides an overview of the current understanding of how its abundance responds to nutrients. These insights offer a theoretical foundation for the utilization of A. muciniphila in immunoregulation.

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全面更新 Akkermansia muciniphila 的免疫调节机制：深入了解活性成分、代谢物和营养素驱动的调节。

Akkermansia muciniphila（A. muciniphila）已被公认为一种先驱性益生菌，在提高人类和动物免疫力方面具有相当大的潜力。粘菌对健康的益处归功于其各种成分，包括外膜蛋白（PilQ 和 Amuc_1100）、分泌蛋白（P9 和 AmTARS）、细胞外囊泡以及 SCFAs、鸟氨酸脂质、γ-氨基丁酸、钴胺素和肌苷等代谢物。粘液虹吸虫对粘液层的动态控制在调节肠粘膜免疫方面起着至关重要的作用。此外，粘液虹吸虫还通过与巨噬细胞、树突状细胞、T 淋巴细胞和 Paneth 细胞相互作用来调节免疫功能。通过营养策略增加肠道中粘液虹鳟鱼的数量是增强免疫功能的一种安全有效的方法。各种多酚、低聚糖和多糖已被证明能提高这种细菌的水平，从而促进有利的免疫调节结果。本文深入探讨了与粘液虹彩菌益生菌机制有关的最新研究进展，并概述了目前对粘液虹彩菌的丰度如何响应营养物质的理解。这些见解为在免疫调节中利用粘菌素提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in food science and nutrition 工程技术-食品科技

CiteScore

22.60

自引率

4.90%

发文量

600

审稿时长

7.5 months

期刊介绍： Critical Reviews in Food Science and Nutrition serves as an authoritative outlet for critical perspectives on contemporary technology, food science, and human nutrition. With a specific focus on issues of national significance, particularly for food scientists, nutritionists, and health professionals, the journal delves into nutrition, functional foods, food safety, and food science and technology. Research areas span diverse topics such as diet and disease, antioxidants, allergenicity, microbiological concerns, flavor chemistry, nutrient roles and bioavailability, pesticides, toxic chemicals and regulation, risk assessment, food safety, and emerging food products, ingredients, and technologies.