Multifaceted role of CTCF in X-chromosome inactivation.

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chromosoma Pub Date : 2024-10-01 Epub Date: 2024-10-21 DOI:10.1007/s00412-024-00826-w

Lakshmi Sowjanya Bammidi, Srimonta Gayen

引用次数: 0

Abstract

Therian female mammals compensate for the dosage of X-linked gene expression by inactivating one of the X-chromosomes. X-inactivation is facilitated by the master regulator Xist long non-coding RNA, which coats the inactive-X and facilitates heterochromatinization through recruiting different chromatin modifiers and changing the X-chromosome 3D conformation. However, many mechanistic aspects behind the X-inactivation process remain poorly understood. Among the many contributing players, CTCF has emerged as one of the key players in orchestrating various aspects related to X-chromosome inactivation by interacting with several other protein and RNA partners. In general, CTCF is a well-known architectural protein, which plays an important role in chromatin organization and transcriptional regulation. Here, we provide significant insight into the role of CTCF in orchestrating X-chromosome inactivation and highlight future perspectives.

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CTCF 在 X 染色体失活中的多方面作用

有巢雌性哺乳动物通过使其中一条X染色体失活来补偿X连锁基因表达的剂量。主调控因子 Xist 长非编码 RNA 促进了 X 的失活，它通过招募不同的染色质修饰因子和改变 X 染色体的三维构象，包裹非活性 X 染色体并促进异染色质化。然而，人们对X失活过程背后的许多机理仍知之甚少。在众多参与者中，CTCF 通过与其他几种蛋白质和 RNA 伙伴相互作用，已成为协调 X 染色体失活相关各方面的关键参与者之一。总的来说，CTCF 是一种众所周知的结构蛋白，在染色质组织和转录调控中发挥着重要作用。在此，我们将深入探讨 CTCF 在协调 X 染色体失活过程中的作用，并强调未来的发展前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chromosoma 生物-生化与分子生物学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear compartments; the nuclear envelope and nucleocytoplasmic interactions, and more. The scope of Chromosoma encompasses genetic, biophysical, molecular and cell biological studies. Average time from receipt of contributions to first decision: 22 days Publishes research and review articles on the functional organization of the eukaryotic cell nucleus Topics include structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis and more Encompasses genetic, biophysical, molecular and cell biological studies.