Sex-Specific Association Patterns of Bone Microstructure and Lower Leg Arterial Calcification.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-11-01 Epub Date: 2024-10-14 DOI:10.1007/s00223-024-01299-w
Mikolaj Bartosik, Alexander Simon, Björn Busse, Florian Barvencik, Michael Amling, Ralf Oheim, Felix N von Brackel
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Abstract

In conversations about bone loss and the importance of calcium homeostasis, patients frequently inquire about the association with arterial calcifications. Although a relationship between bone loss and the occurrence of vascular calcifications is suspected, it is not yet fully investigated and understood. This study aims to analyze associations between bone mineralization, structure, and vascular calcification at the lower leg in patients with low bone mineral density in HR-pQCT. We retrospectively analyzed 774 high-resolution quantitative computed tomography (HR-pQCT) scans of the distal tibia for the presence of vascular calcifications. After sex-specific propensity score matching for age and BMI to account for confounders, 132 patients remained for quantification of bone microstructure, bone density, lower leg arterial calcification (LLAC), and laboratory parameters of bone turnover. The interactions between bone parameters and vascular calcification were quantified by regression analyses. The calcium metabolism was not different between individuals with and without LLAC, nor oral calcium supplementation. Female patients with LLAC had a higher cortical perimeter (p = 0.016) compared to female patients without LLAC, whereas male patients with LLAC had lower cortical pore diameter than male patients without LLAC (p = 0.027). The appearance of LLAC was sex specifically associated with bone parameters. In female patients, only plaque density was associated with HR-pQCT bone parameters and age, whereas in male patients, plaque volume was associated with HR-pQCT parameters of the distal tibia. Female patients exhibit an increasing plaque density depended on age and trabecular thinning. Decreasing cortical pore diameter and trabecular number along with increasing bone mineralization are linked to increasing plaque volume in male patients.

骨微结构与小腿动脉钙化的性别特异性关联模式
在谈论骨质流失和钙平衡的重要性时,患者经常会问到与动脉钙化的关系。虽然人们怀疑骨质流失与血管钙化的发生之间存在关系,但尚未对其进行全面的调查和了解。本研究旨在通过 HR-pQCT 分析低骨矿密度患者小腿处骨矿化、结构和血管钙化之间的关系。我们对 774 例胫骨远端高分辨率定量计算机断层扫描(HR-pQCT)进行了回顾性分析,以确定是否存在血管钙化。在对年龄和体重指数进行性别倾向评分匹配以考虑混杂因素后,我们对 132 名患者的骨微结构、骨密度、小腿动脉钙化(LLAC)和骨转换实验室参数进行了量化。通过回归分析量化了骨参数与血管钙化之间的相互作用。患有和未患有小腿动脉钙化的个体之间的钙代谢没有差异,口服钙补充剂也没有差异。与没有 LLAC 的女性患者相比,患有 LLAC 的女性患者的皮质周长更高(p = 0.016),而患有 LLAC 的男性患者的皮质孔直径低于没有 LLAC 的男性患者(p = 0.027)。LLAC 的出现与骨参数的性别特异性相关。在女性患者中,只有斑块密度与 HR-pQCT 骨参数和年龄相关,而在男性患者中,斑块体积与胫骨远端 HR-pQCT 参数相关。女性患者的斑块密度随年龄和骨小梁变薄而增加。皮质孔直径和骨小梁数量的减少以及骨矿化的增加与男性患者斑块体积的增加有关。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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