Long-Term Reproducibility of BMD-Measurements with Clinical QCT Using Simultaneous and Asynchronous Calibration Methods and Different Measurement and Reconstruction Protocols.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI:10.1007/s00223-024-01303-3
Sophie du Mont, Reinhard Barkmann, Timo Damm, Jaime Peña, Stefan Reinhold, Marcus Both, Meike Mainusch, Claus-Christian Glüer
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引用次数: 0

Abstract

Osteoporosis is underdiagnosed and undertreated. To improve timely fracture risk assessment optimized densitometry methods are required such as opportunistic spinal quantitative computed tomography (QCT). However, it is unclear how to best calibrate these scans and correct for potential scanner drift of QCT when used for monitoring bone mineral density (BMD) changes. We compared gold standard simultaneous calibration with asynchronous calibration methods, assessing mid-term (12 weeks) and long-term (1.5 years) reproducibility of BMD measurements. Cortical and trabecular compartments of the European Spine Phantom were studied with ten different protocols including low dose and high resolution (HR)-modes. Based on weekly phantom data, we compared simultaneous calibration to asynchronous single (termed global) or monthly calibration. The accuracy was better for trabecular measurements than for cortical measurements for all calibration methods. Reproducibility was excellent for all methods and slightly better for asynchronous than for simultaneous calibration both for trabecular and cortical bone. For HR protocols, reproducibility was better than for low dose measurements. In trabecular compartments averaged HR-BMD remained stable for global (- 0.1%/year, ns) but not for simultaneous calibration (- 1.5%/year, p < 0.001). No significant drifts could be detected for averaged low dose BMD (- 0.9 to + 0.8%/year) for either calibration method. Our data suggest that with regard to precision and accuracy measurements with asynchronous calibration are suitable for vertebral BMD assessment (no contrast agents) in clinical practice. Regular (e.g., monthly) stability tests using a calibration phantom could assure long term stability of at least 1 year.

使用同步和异步校准方法以及不同的测量和重建协议进行临床 QCT BMD 测量的长期再现性。
骨质疏松症诊断不足,治疗不力。为了更好地及时评估骨折风险,需要采用优化的骨密度测量方法,如机会性脊柱定量计算机断层扫描(QCT)。然而,目前还不清楚如何对这些扫描进行最佳校准,以及在用于监测骨矿物质密度(BMD)变化时校正 QCT 潜在的扫描仪漂移。我们比较了金标准同步校准和异步校准方法,评估了 BMD 测量的中期(12 周)和长期(1.5 年)可重复性。我们采用十种不同的方案(包括低剂量和高分辨率 (HR) 模式)对欧洲脊柱模型的皮质和骨小梁部分进行了研究。根据每周的模型数据,我们比较了同步校准和异步单一校准(称为全局校准)或每月校准。在所有校准方法中,小梁测量的准确性都优于皮质测量。所有方法的再现性都很好,而异步校准的再现性略高于同步校准,无论是骨小梁还是骨皮质。对于 HR 方案,再现性优于低剂量测量。在骨小梁部分,全局(- 0.1%/年,ns)而非同步校准(- 1.5%/年,p<0.05)的平均 HR-BMD 保持稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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