Prevalence, Clinical Manifestations, and Adverse Outcomes of Left Ventricular Noncompaction in Adults: A Systematic Review and Meta-Analysis.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2024-10-01 Epub Date: 2024-09-16 DOI:10.14740/cr1673

Jordan Llerena-Velastegui, Almendra Lopez-Usina, Camila Mantilla-Cisneros

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引用次数: 0

Abstract

Background: Left ventricular noncompaction (LVNC) is recognized within the spectrum of adult cardiomyopathies for its unique pathophysiologic features and clinical challenges. This condition exhibits a wide range of clinical manifestations, from asymptomatic states to severe cardiovascular complications, making its diagnosis and management challenging. This study aimed to synthesize current data on the prevalence, diagnostic methods, clinical outcomes, and treatment efficacy of LVNC in adults to address gaps in understanding and management strategies.

Methods: A systematic review and meta-analysis of research from 2000 to March 2024 was conducted, focusing on studies involving adults diagnosed with LVNC. This approach aimed to collect data on the prevalence of LVNC, the diagnostic accuracy of different imaging modalities, clinical manifestations, and the impact of different treatment strategies.

Results: The study showed a prevalence of LVNC of 0.5%, with cardiovascular magnetic resonance outperforming echocardiography in diagnosis with a detection rate of 1.3%. Mortality and heart transplantation rates were 12% and 7%, respectively. Significant predictors of adverse outcomes included New York Heart Association (NYHA) class III or IV, ventricular tachycardia, and reduced left ventricular ejection fraction (LVEF), guiding a nuanced approach in tailoring therapeutic strategies to optimize patient care and outcomes.

Conclusions: This study advances the understanding of LVNC by refining diagnostic criteria and evaluating management strategies, highlighting the superiority of cardiovascular magnetic resonance. It identifies predictors of adverse outcomes and assesses treatment efficacy, urging precision in diagnosis and tailored treatments. Its comprehensive analysis and methodological rigor make it a key resource advocating a multidisciplinary approach to improve patient outcomes in LVNC.

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成人左心室不充盈的患病率、临床表现和不良后果：系统回顾与元分析》。

背景：左心室非充盈（LVNC）因其独特的病理生理特点和临床挑战而被认为是成人心肌病中的一种。这种疾病的临床表现范围很广，从无症状状态到严重的心血管并发症，因此其诊断和管理具有挑战性。本研究旨在综合目前有关成人 LVNC 的患病率、诊断方法、临床结果和治疗效果的数据，以弥补认识和管理策略上的不足：方法：对 2000 年至 2024 年 3 月期间的研究进行了系统回顾和荟萃分析，重点关注涉及成人 LVNC 诊断的研究。这种方法旨在收集有关 LVNC 患病率、不同成像模式的诊断准确性、临床表现以及不同治疗策略的影响的数据：研究显示，LVNC 的发病率为 0.5%，心血管磁共振的诊断率高于超声心动图，检出率为 1.3%。死亡率和心脏移植率分别为12%和7%。不良预后的重要预测因素包括纽约心脏协会（NYHA）III级或IV级、室性心动过速和左室射血分数（LVEF）降低，这为定制治疗策略提供了细致入微的指导，以优化患者护理和预后：这项研究通过完善诊断标准和评估管理策略，促进了对 LVNC 的了解，凸显了心血管磁共振的优越性。它确定了不良后果的预测因素并评估了治疗效果，促进了诊断的精确性和治疗的针对性。该研究分析全面、方法严谨，是倡导多学科方法改善 LVNC 患者预后的重要资料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.