Recent strategies in target identification of natural products: Exploring applications in chronic inflammation and beyond.

IF 6.8 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Xian Pan, Shan Jiang, Xinzhuang Zhang, Zhenzhong Wang, Xin Wang, Liang Cao, Wei Xiao
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引用次数: 0

Abstract

Natural products are a treasure trove for drug discovery, especially in the areas of infection, inflammation and cancer, due to their diverse bioactivities and complex, and varied structures. Chronic inflammation is closely related to many diseases, including complex diseases such as cancer and neurodegeneration. Improving target identification for natural products contributes to elucidating their mechanism of action and clinical progress. It also facilitates the discovery of novel druggable targets and the elimination of undesirable ones, thereby significantly enhancing the productivity of drug discovery and development. Moreover, the rise of polypharmacological strategies, considered promising for the treatment of complex diseases, will further increase the demand for target deconvolution. This review underscores strategies for identifying natural product targets (NPs) in the context of chronic inflammation over the past 5 years. These strategies encompass computational methodologies for early target discovery and the anticipation of compound binding sites, proteomics-driven approaches for target delineation and experimental biology techniques for target validation and comprehensive mechanistic exploration.

天然产品目标识别的最新战略:探索慢性炎症及其他方面的应用。
天然产物具有多种生物活性和复杂多样的结构,是药物发现的宝库,尤其是在感染、炎症和癌症领域。慢性炎症与许多疾病密切相关,包括癌症和神经变性等复杂疾病。改进天然产品的靶点鉴定有助于阐明其作用机制和临床进展。它还有助于发现新的可药用靶点并消除不良靶点,从而显著提高药物发现和开发的效率。此外,被认为有望治疗复杂疾病的多药理策略的兴起将进一步增加对靶点解旋的需求。本综述强调了过去五年来在慢性炎症背景下确定天然产物靶点(NPs)的策略。这些策略包括用于早期靶点发现和化合物结合位点预测的计算方法、用于靶点界定的蛋白质组学驱动方法以及用于靶点验证和全面机理探索的实验生物学技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
15.40
自引率
12.30%
发文量
270
审稿时长
2.0 months
期刊介绍: The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.
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