Neuronal Vulnerability of the Entorhinal Cortex to Tau Pathology in Alzheimer's Disease.

IF 2.7 4区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
British Journal of Biomedical Science Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.3389/bjbs.2024.13169
Simi Zhang, Chelsea Ann Crossley, Qi Yuan
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引用次数: 0

Abstract

This review delves into the entorhinal cortex (EC) as a central player in the pathogenesis of Alzheimer's Disease (AD), emphasizing its role in the accumulation and propagation of tau pathology. It elucidates the multifaceted functions of the EC, encompassing memory formation, spatial navigation, and olfactory processing, while exploring how disruptions in these processes contribute to cognitive decline in AD. The review discusses the intricate interplay between tau pathology and EC vulnerability, highlighting how alterations in neuronal firing patterns and synaptic function within the EC exacerbate cognitive impairments. Furthermore, it elucidates how specific neuronal subtypes within the EC exhibit differential susceptibility to tau-induced damage, contributing to disease progression. Early detection methods, such as imaging techniques and assessments of EC blood flow, are examined as potential tools for identifying tau pathology in the preclinical stages of AD. These approaches offer promise for improving diagnostic accuracy and enabling timely intervention. Therapeutic strategies targeting tau pathology within the EC are explored, including the clearance of pathological tau aggregates and the inhibition of tau aggregation processes. By understanding the molecular and cellular mechanisms underlying EC vulnerability, researchers can develop more targeted and effective interventions to slow disease progression. The review underscores the importance of reliable biomarkers to assess disease progression and therapeutic efficacy in clinical trials targeting the EC. Ultimately, it aims to contribute to the development of more effective management strategies for AD, emphasizing the translation of research findings into clinical practice to address the growing societal burden of the disease.

阿尔茨海默病中内侧皮层神经元对 Tau 病理学的脆弱性
这篇综述深入探讨了作为阿尔茨海默病(AD)发病机制核心参与者的内含皮层(EC),强调了它在tau病理学的积累和传播中的作用。综述阐明了脑内皮层的多方面功能,包括记忆形成、空间导航和嗅觉处理,同时探讨了这些过程的破坏是如何导致阿尔茨海默病认知能力下降的。综述讨论了tau病理学和EC脆弱性之间错综复杂的相互作用,强调了EC内神经元发射模式和突触功能的改变如何加剧认知障碍。此外,文章还阐明了EC中的特定神经元亚型如何对tau诱导的损伤表现出不同的易感性,从而导致疾病进展。研究还探讨了早期检测方法,如成像技术和EC血流评估,作为在AD临床前阶段识别tau病理学的潜在工具。这些方法有望提高诊断的准确性并实现及时干预。研究还探讨了针对心血管内tau病理学的治疗策略,包括清除病理性tau聚集体和抑制tau聚集过程。通过了解心肌脆弱的分子和细胞机制,研究人员可以开发出更有针对性、更有效的干预措施,以延缓疾病的进展。本综述强调了在针对心肌梗死的临床试验中使用可靠的生物标志物来评估疾病进展和疗效的重要性。综述的最终目的是为制定更有效的AD管理策略做出贡献,强调将研究成果转化为临床实践,以应对该疾病日益加重的社会负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Biomedical Science
British Journal of Biomedical Science 医学-医学实验技术
CiteScore
4.40
自引率
15.80%
发文量
29
审稿时长
>12 weeks
期刊介绍: The British Journal of Biomedical Science is committed to publishing high quality original research that represents a clear advance in the practice of biomedical science, and reviews that summarise recent advances in the field of biomedical science. The overall aim of the Journal is to provide a platform for the dissemination of new and innovative information on the diagnosis and management of disease that is valuable to the practicing laboratory scientist.
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