Cardiorespiratory stability in critically ill preterm infants following dexmedetomidine initiation.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2024-10-18 DOI:10.1055/a-2445-3010

Brynne Archer Sullivan, Angela K S Gummadi, Paige Howard, Hayley Kendrick, Brandy Zeller, Christopher McPherson, Zachary A Vesoulis

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引用次数: 0

Abstract

Objective: To evaluate cardiorespiratory status in preterm infants receiving dexmedetomidine using high-resolution physiologic data.

Study design: We analyzed preterm infants with continuous heart rate (HR) and oxygen saturation (SpO2) data for 24 hours preceding and 48 hours following dexmedetomidine initiation. Invasive arterial blood pressure (ABP), when available, was analyzed.

Results: In 100 infants with mean gestational age of 28 weeks and high baseline illness severity, mean HR decreased from 152 to 141 beats per minute while mean SpO2 increased from 91% to 93% in the 48 hours after dexmedetomidine initiation (p<0.01). In 57 infants with continuous ABP monitoring, mean ABP increased from 40 to 42 mmHg (p=0.01). Vasoactive-inotropic support increased before and after initiation.

Conclusions: We observed cardiorespiratory changes in critically ill preterm infants following dexmedetomidine initiation; mean HR decreased and mean SpO2 increased in the 48 hours after initiation. In a subset, mean ABP increased along with vasoactive-inotropic support.

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重症早产儿使用右美托咪定后心肺功能稳定。

研究目的利用高分辨率生理数据评估接受右美托咪定治疗的早产儿的心肺功能状况：研究设计：我们分析了早产儿在使用右美托咪定之前 24 小时和之后 48 小时的连续心率 (HR) 和血氧饱和度 (SpO2) 数据。如果可以获得有创动脉血压 (ABP)，则对其进行分析：结果：在 100 名平均胎龄为 28 周、基线疾病严重程度较高的婴儿中，开始使用右美托咪定后 48 小时内，平均心率从每分钟 152 次降至 141 次，而平均 SpO2 从 91% 上升至 93%（p结论：我们观察到了心肺功能的变化：我们观察到，使用右美托咪定后，危重早产儿的心肺功能发生了变化；在使用右美托咪定后的 48 小时内，平均心率下降，平均 SpO2 上升。在一部分婴儿中，随着血管活性-肌力支持的增加，平均 ABP 也随之升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.