Amyloid deposition and its association with depressive symptoms and cognitive functions in late-life depression: a longitudinal study using amyloid-β PET images and neuropsychological measurements.

IF 7.9 1区 医学 Q1 CLINICAL NEUROLOGY
Kiwon Kim, Yoo Jin Jang, Jeong-Hyeon Shin, Mi Jin Park, Hyun Soo Kim, Joon-Kyung Seong, Hong Jin Jeon
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引用次数: 0

Abstract

Background: Although depression is linked to an increased risk of dementia, the association between late-onset depression (LOD) and amyloid burden remains unclear. This study aimed to determine amyloid deposition in patients with LOD compared to healthy controls (HC) using amyloid-beta (Aβ) positron emission tomography (PET) images and neuropsychological assessments.

Methods: Forty patients first diagnosed with major depressive disorder after the age of 60 (LOD) and twenty-one healthy volunteers (HC) were enrolled. Depression and anxiety were evaluated using the 17-item Hamilton Depression Scale, Hamilton Anxiety Rating Scale, and Clinical Global Impression Scale. Cognitive function was assessed using the Korean versions of the Mini-Mental Status Examination, Montreal Cognitive Assessment, and Seoul Neuropsychological Screening Battery at baseline and 3-month follow-up. 18F-florbetapir PET images were co-registered with T1-weighted magnetic resonance images.

Results: There was no significant difference in Aβ deposition between LOD and HC groups. No significant correlation between Aβ burden and depressive symptom severity was found in LOD patients. Higher somatic anxiety was correlated with lower Aβ burden in multiple brain regions, including the left inferior frontal lobe (p = 0.009), right anterior cingulate (p = 0.003), and right superior frontal lobe (p = 0.009). Despite cognitive recovery in areas such as attention (Digit Span Forward, p = 0.026), memory (Auditory Verbal Learning Test Recall Total, p = 0.010; Rey Complex Figure Test Delayed Recall, p = 0.039), and frontal executive function (Contrasting Program, p = 0.033) after three months of antidepressant treatment, cognitive improvement showed no association with amyloid deposition.

Conclusions: These findings suggest distinct mechanisms may underlie amyloid deposition in neurodegenerative changes associated with depression. While amyloid burden in specific brain regions negatively correlated with somatic anxiety, it showed no significant correlation with the severity of depression or overall cognitive function.

晚年抑郁症患者的淀粉样蛋白沉积及其与抑郁症状和认知功能的关系:一项使用淀粉样蛋白-β PET 图像和神经心理学测量方法进行的纵向研究。
背景:尽管抑郁症与痴呆症风险增加有关,但晚发性抑郁症(LOD)与淀粉样蛋白负担之间的关系仍不清楚。本研究旨在通过淀粉样蛋白-β(Aβ)正电子发射断层扫描(PET)图像和神经心理学评估,确定晚发性抑郁症患者与健康对照组(HC)相比的淀粉样蛋白沉积情况:方法:研究人员招募了 40 名 60 岁后首次被诊断为重度抑郁障碍的患者(LOD)和 21 名健康志愿者(HC)。采用 17 项汉密尔顿抑郁量表、汉密尔顿焦虑评定量表和临床整体印象量表对抑郁和焦虑进行评估。在基线和 3 个月的随访中,使用韩国版迷你精神状态检查、蒙特利尔认知评估和首尔神经心理筛查电池评估认知功能。18F-氟贝他匹PET图像与T1加权磁共振图像共同登记:结果:LOD组和HC组的Aβ沉积无明显差异。在 LOD 患者中,Aβ 负担与抑郁症状严重程度之间没有发现明显的相关性。较高的躯体焦虑与多个脑区较低的 Aβ 负荷相关,包括左下额叶(p = 0.009)、右前扣带回(p = 0.003)和右上额叶(p = 0.009)。尽管经过三个月的抗抑郁治疗后,注意力(数字跨度前向,p = 0.026)、记忆力(听觉言语学习测试总回忆,p = 0.010;Rey复杂图形测试延迟回忆,p = 0.039)和额叶执行功能(对比程序,p = 0.033)等方面的认知能力有所恢复,但认知能力的改善与淀粉样蛋白沉积没有关联:这些研究结果表明,与抑郁症相关的神经退行性病变中的淀粉样蛋白沉积可能存在不同的机制。虽然特定脑区的淀粉样蛋白负荷与躯体焦虑呈负相关,但与抑郁症的严重程度或整体认知功能并无明显关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy 医学-神经病学
CiteScore
13.10
自引率
3.30%
发文量
172
审稿时长
>12 weeks
期刊介绍: Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
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