Lizhi Fang, Xiaowen Guan, Yanling Shen, Dayang Zhou, Long Chen, Xiaochuan Chen, Wanhua Wu, Leyong Wang, Cheng Yang
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引用次数: 0
Abstract
Halogen-substituted pillar[5]arenes exhibited hindered hydroquinone subunit flipping, enabling enantioseparation. An enantiopure conformer demonstrated a dissymmetric factor of 0.012 and an enantioselective binding ratio exceeding 1.92. Complexation with L-serine induced an enantiopreference in the pillar[5]arene, which persisted for a certain period after chiral inducer removal and reversed upon the addition of D-serine. This induced enantiopreference was subsequently transferred to a chromophore guest, achieving a multi-step chiral transfer process. This approach offers a potential alternative to traditional chiral HPLC methods, enabling the manipulation of chiral recognition and transfer through chiral inducers.
期刊介绍:
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.