Lewis Acid-Controlled Pd-Catalyzed Chemodivergent Hydrocyanation of Cyclopropenes

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-10-22 DOI:10.1039/d4qo01609b

Rongrong Yu, Song-Zhou Cai, Xianjie Fang

引用次数: 0

Abstract

Due to the multifaceted reactivities of cyclopropenes, the divergent hydrofunctionalization of these compounds has recently attracted significant attention. Herein, we present a Pd-catalyzed hydrocyanation of cyclopropenes via aluminum Lewis acid-controlled divergent chemoselectivity. In this study, the presence of aluminum Lewis acid plays an pivotal role on the reaction pathway. In the absence of aluminum Lewis acid, the reaction predominantly yields ring-opening hydrocyanation products, whereas the addition of Lewis acid directs the formation of ring-retentive products.

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路易斯酸控制的钯催化环丙烯化学歧化加氢氰化反应

由于环丙烯具有多方面的反应活性，这些化合物的发散氢功能化最近引起了极大的关注。在此，我们介绍了通过路易斯酸铝控制的发散化学选择性来催化环丙烯的氢氰化反应。在这项研究中，铝路易斯酸的存在对反应途径起着关键作用。在没有路易斯酸铝的情况下，反应主要产生开环氢氰化产物，而路易斯酸的加入则会引导环保留产物的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.