Global cancer statistics for adolescents and young adults: population based study

IF 29.5 1区医学 Q1 HEMATOLOGY

Journal of Hematology & Oncology Pub Date : 2024-10-21 DOI:10.1186/s13045-024-01623-9

Wangzhong Li, Hengrui Liang, Wei Wang, Jun Liu, Xiwen Liu, Shen Lao, Wenhua Liang, Jianxing He

{"title":"Global cancer statistics for adolescents and young adults: population based study","authors":"Wangzhong Li, Hengrui Liang, Wei Wang, Jun Liu, Xiwen Liu, Shen Lao, Wenhua Liang, Jianxing He","doi":"10.1186/s13045-024-01623-9","DOIUrl":null,"url":null,"abstract":"Accurate and up-to-date estimates of the global cancer burden in adolescents and young adults (AYA) are scarce. This study aims to assess the global burden and trends of AYA cancer, with a focus on socioeconomic disparities, to inform global cancer control strategies. AYA cancer, defined as cancer occurring in individuals aged 15–39, was analyzed using data from the Global Burden of Disease (GBD) 2021 study and the Global Cancer Observatory (GLOBOCAN) 2022 project. We examined the global burden by age, sex, geographic location, and Human Development Index (HDI), as well as its temporal trends. Primary outcomes included age-standardized incidence and mortality rates (ASIR, ASMR) and the average annual percent change (AAPC). In 2022, an estimated 1,300,196 incidental cases and 377,621 cancer-related deaths occurred among AYAs worldwide, with an ASIR of 40.3 per 100,000 and an ASMR of 11.8 per 100,000. The most common cancers were breast, thyroid, and cervical, while the leading causes of death were breast, cervical, and leukemia. The incidence and mortality were disproportionately higher among females (ASIR: 52.9 for females vs. 28.3 for males; ASMR: 13.1 for females vs. 10.6 for males). Countries with higher HDI experienced a higher incidence of AYA cancers (ASIR: 32.0 [low HDI] vs. 54.8 [very high HDI]), while countries with lower HDI faced a disproportionately higher mortality burden (ASMR: 17.2 [low HDI] vs. 8.4 [very high HDI]) despite their relatively low incidence. Disproportionality and regression measures highlighted significant HDI-related inequalities. AYA cancer incidence was stable from 2000 to 2011 (AAPC: − 0.04) but increased from 2012 to 2021 (AAPC: 0.53), driven by growing gonadal and colorectal cancers. Mortality decreased substantially from 2000 to 2011 (AAPC: − 1.64), but the decline slowed from 2012 (AAPC: − 0.32) probably due to increased deaths from gonadal cancers. These trends varied by sex, cancer type, geography, and HDI. AYA cancers present a significant and growing global burden, with marked disparities across sex, geographic locations, and HDI levels. Policymakers should prioritize equitable resource allocation and implement targeted interventions to reduce these inequalities, particularly in low-HDI regions and with regard to gonadal cancers.","PeriodicalId":16023,"journal":{"name":"Journal of Hematology & Oncology","volume":"67 1","pages":""},"PeriodicalIF":29.5000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hematology & Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13045-024-01623-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Accurate and up-to-date estimates of the global cancer burden in adolescents and young adults (AYA) are scarce. This study aims to assess the global burden and trends of AYA cancer, with a focus on socioeconomic disparities, to inform global cancer control strategies. AYA cancer, defined as cancer occurring in individuals aged 15–39, was analyzed using data from the Global Burden of Disease (GBD) 2021 study and the Global Cancer Observatory (GLOBOCAN) 2022 project. We examined the global burden by age, sex, geographic location, and Human Development Index (HDI), as well as its temporal trends. Primary outcomes included age-standardized incidence and mortality rates (ASIR, ASMR) and the average annual percent change (AAPC). In 2022, an estimated 1,300,196 incidental cases and 377,621 cancer-related deaths occurred among AYAs worldwide, with an ASIR of 40.3 per 100,000 and an ASMR of 11.8 per 100,000. The most common cancers were breast, thyroid, and cervical, while the leading causes of death were breast, cervical, and leukemia. The incidence and mortality were disproportionately higher among females (ASIR: 52.9 for females vs. 28.3 for males; ASMR: 13.1 for females vs. 10.6 for males). Countries with higher HDI experienced a higher incidence of AYA cancers (ASIR: 32.0 [low HDI] vs. 54.8 [very high HDI]), while countries with lower HDI faced a disproportionately higher mortality burden (ASMR: 17.2 [low HDI] vs. 8.4 [very high HDI]) despite their relatively low incidence. Disproportionality and regression measures highlighted significant HDI-related inequalities. AYA cancer incidence was stable from 2000 to 2011 (AAPC: − 0.04) but increased from 2012 to 2021 (AAPC: 0.53), driven by growing gonadal and colorectal cancers. Mortality decreased substantially from 2000 to 2011 (AAPC: − 1.64), but the decline slowed from 2012 (AAPC: − 0.32) probably due to increased deaths from gonadal cancers. These trends varied by sex, cancer type, geography, and HDI. AYA cancers present a significant and growing global burden, with marked disparities across sex, geographic locations, and HDI levels. Policymakers should prioritize equitable resource allocation and implement targeted interventions to reduce these inequalities, particularly in low-HDI regions and with regard to gonadal cancers.

查看原文本刊更多论文

全球青少年和年轻成人癌症统计数据：基于人口的研究

对全球青少年和年轻成人（AYA）癌症负担的最新准确估算还很少。本研究旨在评估全球青少年癌症负担和趋势，重点关注社会经济差异，为全球癌症控制策略提供参考。青少年癌症是指发生在 15-39 岁人群中的癌症，本研究利用 2021 年全球疾病负担（GBD）研究和 2022 年全球癌症观察站（GLOBOCAN）项目的数据对青少年癌症进行了分析。我们研究了按年龄、性别、地理位置和人类发展指数（HDI）划分的全球负担及其时间趋势。主要结果包括年龄标准化发病率和死亡率（ASIR、ASMR）以及年均百分比变化（AAPC）。2022 年，全球青少年中估计有 1,300,196 例偶发病例和 377,621 例癌症相关死亡病例，年龄标准化发病率为每 10 万人 40.3 例，年龄标准化死亡率为每 10 万人 11.8 例。最常见的癌症是乳腺癌、甲状腺癌和宫颈癌，而主要死因是乳腺癌、宫颈癌和白血病。女性的发病率和死亡率高得不成比例（ASIR：女性 52.9 例，男性 28.3 例；ASMR：女性 13.1 例，男性 10.6 例）。在人类发展指数较高的国家，青少年癌症的发病率较高（ASIR：32.0[低人类发展指数] vs. 54.8[极高人类发展指数]），而在人类发展指数较低的国家，尽管发病率相对较低，但死亡率却高得不成比例（ASMR：17.2[低人类发展指数] vs. 8.4[极高人类发展指数]）。比例失调和回归测量凸显了与人类发展指数相关的严重不平等。2000 年至 2011 年，亚裔青少年癌症发病率保持稳定（亚裔青少年癌症发病率：- 0.04），但 2012 年至 2021 年，受性腺癌和结肠直肠癌增加的影响，发病率有所上升（亚裔青少年癌症发病率：0.53）。2000 年至 2011 年，死亡率大幅下降（美国癌症协会：- 1.64），但从 2012 年开始下降速度放缓（美国癌症协会：- 0.32），这可能是由于性腺癌症导致的死亡人数增加。这些趋势因性别、癌症类型、地域和人类发展指数而异。青壮年癌症给全球带来了巨大且不断增长的负担，不同性别、不同地理位置和不同人类发展指数水平之间存在明显差异。政策制定者应优先考虑公平的资源分配，并实施有针对性的干预措施，以减少这些不平等现象，尤其是在低人类发展指数地区和性腺癌症方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Hematology & Oncology 医学-血液学

CiteScore

48.10

自引率

2.10%

发文量

169

审稿时长

6-12 weeks

期刊介绍： The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.