Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer.

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2024-10-18 DOI:10.1158/1078-0432.ccr-24-2738

Jesús Bravo Melgar,Damya Laoui

引用次数: 0

Abstract

Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment.

查看原文本刊更多论文

化疗激发转移性卵巢癌的三级淋巴结构

大多数卵巢癌患者对免疫疗法仍有抵抗力，这凸显了提高这些肿瘤免疫原性的必要性。最近的一项研究揭示了化疗如何在转移性卵巢癌中诱导癌细胞应激，诱导三级淋巴结构的形成，从而创造一个 "更热 "的肿瘤微环境。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.