R-loops’ m6A modification and its roles in cancers

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2024-10-18 DOI:10.1186/s12943-024-02148-y

Yue Qiu, Changfeng Man, Luyu Zhu, Shiqi Zhang, Xiaoyan Wang, Dandan Gong, Yu Fan

引用次数: 0

Abstract

R-loops are three-stranded nucleic acid structures composed of an RNA–DNA hybrid and a displaced DNA strand. They are widespread and play crucial roles in regulating gene expression, DNA replication, and DNA and histone modifications. However, their regulatory mechanisms remain unclear. As R-loop detection technology advances, changes in R-loop levels have been observed in cancer models, often associated with transcription-replication conflicts and genomic instability. N6-methyladenosine (m6A) is an RNA epigenetic modification that regulates gene expression by affecting RNA localization, splicing, translation, and degradation. Upon reviewing the literature, we found that R-loops with m6A modifications are implicated in tumor development and progression. This article summarizes the molecular mechanisms and detection methods of R-loops and m6A modifications in gene regulation, and reviews recent research on m6A-modified R-loops in oncology. Our goal is to provide new insights into the origins of genomic instability in cancer and potential strategies for targeted therapy.

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R 环的 m6A 修饰及其在癌症中的作用

R 环是一种三链核酸结构，由一条 RNA-DNA 杂交链和一条移位的 DNA 链组成。它们广泛存在，在调控基因表达、DNA 复制以及 DNA 和组蛋白修饰方面发挥着重要作用。然而，它们的调控机制仍不清楚。随着 R 环检测技术的发展，在癌症模型中观察到了 R 环水平的变化，这种变化往往与转录复制冲突和基因组不稳定性有关。N6-甲基腺苷（m6A）是一种 RNA 表观遗传修饰，通过影响 RNA 定位、剪接、翻译和降解来调控基因表达。通过查阅文献，我们发现带有 m6A 修饰的 R 环与肿瘤的发生和发展有关。本文总结了 R 环和 m6A 修饰在基因调控中的分子机制和检测方法，并回顾了肿瘤学中有关 m6A 修饰 R 环的最新研究。我们的目标是为癌症基因组不稳定性的起源和潜在的靶向治疗策略提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

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