Jingyi Lu, Jiaying Ni, Hang Su, Xingxing He, Wei Lu, Wei Zhu, Yufei Wang, Xiaojing Ma, Yuqian Bao, Jian Zhou
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引用次数: 0
Abstract
There is evidence that 1-h plasma glucose (PG) during the 75-g oral glucose tolerance test (OGTT) is superior to 2-h PG in predicting diabetes. We aimed to investigate the characteristics of insulin sensitivity and β-cell function behind this observation. After age, sex and BMI matching, 496 subjects selected from 3965 non-diabetic individuals at high risk of type 2 diabetes in a tertiary medical center were categorized into four groups in a 1:1:1:1 ratio based on OGTT results: 1) 1 h < 8.6 mmol/L and 2 h < 7.8 mmol/L (normal glucose tolerance [NGT] /1h-normal); 2) 1 h ≥ 8.6 mmol/L and 2 h < 7.8 mmol/L (NGT/1h-high); 3) 1 h < 8.6 mmol/L and 2 h ≥ 7.8 mmol/L (impaired glucose tolerance [IGT]/1h-normal); and 4) 1 h ≥ 8.6 mmol/L and 2 h ≥ 7.8 mmol/L (IGT/1h-high). Compared with subjects with IGT/1h-normal, those with NGT/1h-high exhibited similar extent of insulin resistance but lower early-phase insulin secretion. Additionally, participants with NGT/1h-high had lower disposition index at both 0-30 min and 0-120 min than those with IGT/1h-normal. The fitted regression line relating PG to log-transformed disposition index (0-30 min and 0-120 min) was significantly steeper for 1-h than 2-h PG. In conclusion, 1-h PG seemed to be more sensitive to the deterioration in β-cell function than 2-h PG. The use of 1-h PG may identify individuals at high risk of type 2 diabetes at an earlier stage
期刊介绍:
Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes.
However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.