Semi-synthesis of a DNA-Tagged Polyketide–Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-10-16 DOI:10.1021/acs.orglett.4c03588

Soya Koremura, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai

引用次数: 0

Abstract

Presented herein is a synthetic biological method using genome mining and heterologous expression systems that provides access to natural products with desirable structural features as building blocks. In this investigation, we synthesized polyketide–peptide hybrid macrocycles with DNA tags, which have the potential to access a DNA-encoded library containing over one million compounds. This study demonstrates that synthetic biology offers a tool for expanding the diversity of building blocks, facilitating the exploration of unexplored chemical space.

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以生物合成的真菌大环内酯为合成组分半合成 DNA 标记的多酮肽杂交大环

本文介绍的是一种利用基因组挖掘和异源表达系统的合成生物学方法，这种方法可以获得具有理想结构特征的天然产品作为构建模块。在这项研究中，我们合成了带有 DNA 标记的多酮肽杂交大环，这种方法有可能获得包含 100 多万种化合物的 DNA 编码库。这项研究表明，合成生物学为扩大构建模块的多样性提供了一种工具，有助于探索尚未开发的化学空间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.