Tumor hypoxia: long ignored but now detectable and potentially actionable.

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2024-10-16 DOI:10.1158/1078-0432.ccr-24-2626

Ralph P Mason

引用次数: 0

Abstract

Oxygen-enhanced MRI was successfully applied to 24 patients with HPV-associated oropharyngeal cancer. This prospective trial rigorously evaluated reproducibility and changes with respect to tumor radiation. Analyses compared hypoxic volumes and hypoxic fractions. It represents important progress in developing a practical approach to assessing tumor hypoxia in patients noninvasively.

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肿瘤缺氧：长期被忽视，但现在可检测到并有可能采取行动。

氧增强核磁共振成像成功应用于24例HPV相关口咽癌患者。这项前瞻性试验严格评估了重现性和与肿瘤辐射有关的变化。分析比较了缺氧体积和缺氧分数。它标志着在开发无创评估患者肿瘤缺氧的实用方法方面取得了重要进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.