Cytosolic acetyl-CoA synthesis shields mitochondria from stress in brown adipocytes

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-10-15 DOI:10.1038/s42255-024-01152-2

引用次数: 0

Abstract

Brown adipose tissue (BAT) facilitates thermogenesis through fatty acid oxidation (FAO). Paradoxically, BAT simultaneously increases anabolic fatty acid synthesis (FAS), the reason for which is unclear. We provide evidence that thermogenic mitochondria within brown adipocytes export TCA cycle intermediates that fuel de novo lipid synthesis, in part to protect against metabolic stress.

Abstract Image

查看原文本刊更多论文

细胞膜乙酰-CoA 合成保护线粒体免受棕色脂肪细胞压力的影响

棕色脂肪组织（BAT）通过脂肪酸氧化（FAO）促进产热。矛盾的是，棕色脂肪组织同时增加了合成代谢脂肪酸（FAS），其原因尚不清楚。我们提供的证据表明，棕色脂肪细胞内的产热线粒体会输出 TCA 循环中间产物，以促进脂质的从头合成，这在一定程度上是为了抵御代谢压力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.