Feasibility of intravenous vitamin C supplementation in allogeneic hematopoietic cell transplant recipients

EJHaem Pub Date : 2024-08-27 DOI:10.1002/jha2.995
Gary L. Simmons, Roy Sabo, Rehan Qayyum, May Aziz, Erika Martin, Robyn J. Bernard, Manjari Sriparna, Cody McIntire, Elizabeth Krieger, Donald F. Brophy, Ramesh Natarajan, Alpha Fowler III, Catherine H. Roberts, Amir Toor
{"title":"Feasibility of intravenous vitamin C supplementation in allogeneic hematopoietic cell transplant recipients","authors":"Gary L. Simmons,&nbsp;Roy Sabo,&nbsp;Rehan Qayyum,&nbsp;May Aziz,&nbsp;Erika Martin,&nbsp;Robyn J. Bernard,&nbsp;Manjari Sriparna,&nbsp;Cody McIntire,&nbsp;Elizabeth Krieger,&nbsp;Donald F. Brophy,&nbsp;Ramesh Natarajan,&nbsp;Alpha Fowler III,&nbsp;Catherine H. Roberts,&nbsp;Amir Toor","doi":"10.1002/jha2.995","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Intravenous vitamin C was administered following hematopoietic stem cell transplant to mitigate nonrelapse mortality (NRM) in a Phase II clinical trial.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Patients with advanced hematologic malignancies received IV vitamin C, 50 mg/kg/day, in three divided doses on days 1–14 after HSCT, followed by 500 mg bid oral until 6 months.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>All patients enrolled (55) were deficient in vitamin C at day 0 and had restoration to normal levels. Vitamin C recipients had a trend for lower nonrelapse mortality (NRM, 11% vs. 25%, <i>p</i>-value = 0.07) compared with propensity score-matched historical controls. A similar trend toward improved survival was observed (82% vs. 62% <i>p</i> = 0.06), with no attributable grade 3 and 4 toxicities to vitamin C.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In patients undergoing allogeneic HSCT, repletion of vitamin C is feasible and may reduce NRM and improve overall survival. Randomized trials in large uniform cohorts of patients are needed to confirm the utility of this easily available and inexpensive therapy.</p>\n </section>\n </div>","PeriodicalId":72883,"journal":{"name":"EJHaem","volume":"5 5","pages":"1043-1047"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jha2.995","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJHaem","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jha2.995","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Intravenous vitamin C was administered following hematopoietic stem cell transplant to mitigate nonrelapse mortality (NRM) in a Phase II clinical trial.

Methods

Patients with advanced hematologic malignancies received IV vitamin C, 50 mg/kg/day, in three divided doses on days 1–14 after HSCT, followed by 500 mg bid oral until 6 months.

Results

All patients enrolled (55) were deficient in vitamin C at day 0 and had restoration to normal levels. Vitamin C recipients had a trend for lower nonrelapse mortality (NRM, 11% vs. 25%, p-value = 0.07) compared with propensity score-matched historical controls. A similar trend toward improved survival was observed (82% vs. 62% p = 0.06), with no attributable grade 3 and 4 toxicities to vitamin C.

Conclusion

In patients undergoing allogeneic HSCT, repletion of vitamin C is feasible and may reduce NRM and improve overall survival. Randomized trials in large uniform cohorts of patients are needed to confirm the utility of this easily available and inexpensive therapy.

Abstract Image

异体造血细胞移植受者静脉补充维生素 C 的可行性
导言:在一项 II 期临床试验中,造血干细胞移植后静脉注射维生素 C 以降低非复发死亡率(NRM)。 方法 晚期血液恶性肿瘤患者在造血干细胞移植后第 1-14 天分三次静脉注射维生素 C,每次 50 毫克/千克/天,之后口服 500 毫克,每次 6 个月。 结果 所有入组患者(55 人)在第 0 天均缺乏维生素 C,但随后均恢复到正常水平。与倾向评分匹配的历史对照组相比,维生素 C 接受者的非复发死亡率(NRM,11% 对 25%,P 值 = 0.07)呈下降趋势。结论 在接受异基因造血干细胞移植的患者中,补充维生素 C 是可行的,可降低 NRM 并提高总生存率。需要在大型统一患者队列中进行随机试验,以确认这种易于获得且价格低廉的疗法的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信