Single-centre experience of implementing physiotherapist-led prehabilitation for chimeric antigen receptor T cell therapy

EJHaem Pub Date : 2024-09-23 DOI:10.1002/jha2.1006

Orla McCourt, Paul Maciocia, Claire Roddie, Angela Hwang, Leigh Wood, Aikaterini Panopoulou, Deborah Ann Springell, Maise Al Bakir, Maeve O'Reilly

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Abstract

Introduction

This report outlines the evaluation of physiotherapist-led prehabilitation/rehabilitation for recipients of chimeric antigen receptor T (CAR-T) cell therapy.

Methods

A hybrid approach was used, incorporating in-person assessment of quality of life and functional capacity (6-min walk test and timed sit-to-stand test), and a personalised home exercise programme with remotely delivered physiotherapist support pre/post-admission.

Results

Functional deficits were prevalent at referral for CAR-T. Prehabilitation and rehabilitation were highly acceptable to patients, and improvements in functional capacity were documented pre-admission.

Conclusion

This data highlights the importance of pre-CAR-T functional assessment and prehabilitation to optimise preparation and recovery.

Abstract Image

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由物理治疗师主导的嵌合抗原受体 T 细胞疗法前期康复的单中心实施经验

简介：本报告概述了对嵌合抗原受体 T（CAR-T）细胞疗法受者进行理疗师指导的康复前/康复训练的评估。方法采用了一种混合方法，包括亲自评估生活质量和功能能力（6 分钟步行测试和定时坐立测试），以及入院前/后物理治疗师远程支持的个性化家庭锻炼计划。结果 CAR-T 转诊时普遍存在功能障碍。患者对康复前和康复治疗的接受度很高，入院前的记录显示患者的功能能力有所改善。结论这些数据强调了 CAR-T 前功能评估和康复训练对优化准备和恢复的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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EJHaem

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