Serum Neurofilament Light Chain Levels Correlate With Skin Inflammation and Scratch Lesions in Patients With Pruritus

IF 3.7 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2024-10-13 DOI:10.1155/2024/3542876

Simon M. Mueller, Jie Zhu, Oliver Brandt, Alexander A. Navarini, Oezguer Yaldizli, Athina Papadopoulou, Jens Kuhle

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Abstract

Background: Neurofilament light chain (NfL) has been identified as a biomarker in neuroaxonal injury. Cutaneous nerve injury resulting from inflammation and/or forced scratching may also potentially affect serum NfL (sNfL) levels.

Objectives: We aimed to explore the relationship between sNfL levels and the severity of skin inflammation and scratch lesions in patients with pruritus.

Methods: In this cross-sectional pilot study, we measured the sNfL levels of 10 patients with pruritus of different aetiologies, and calculated age- and BMI-adjusted sNfL percentiles based on a normative database consisting of 4532 control individuals. Next, we investigated the relationship between the levels of sNfL and the severity of skin inflammation and scratching injuries in these patients using a newly-created Skin Inflammation and Scratch Lesions (SISL) score.

Results: A positive correlation was observed between sNfL levels and the severity of skin inflammation and scratch lesions as measured by the SISL score (Spearman’s rho = 0.70, p = 0.031). When correlated separately, both the “skin inflammation only” and “scratch lesions only” scores correlated positively with sNfL levels (Spearman’s rho = 0.68, p = 0.031; Spearman’s rho = 0.66, p = 0.041, respectively).

Conclusions: sNfL may be a potential biomarker for cutaneous nerve injury associated with skin inflammation and/or scratching.

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血清神经丝蛋白轻链水平与瘙痒症患者的皮肤炎症和划痕病变有关

背景：神经丝蛋白轻链（NfL神经丝蛋白轻链（NfL）已被确定为神经轴突损伤的生物标志物。炎症和/或强迫搔抓导致的皮肤神经损伤也可能影响血清神经丝蛋白轻链（sNfL）的水平。研究目的我们旨在探索 sNfL 水平与瘙痒症患者皮肤炎症和抓痕严重程度之间的关系。研究方法在这项横断面试验研究中，我们测量了 10 名不同病因的瘙痒症患者的 sNfL 水平，并根据由 4532 名对照个体组成的常模数据库计算了经年龄和体重指数调整的 sNfL 百分位数。接着，我们使用新创建的皮肤炎症和抓痕损伤（SISL）评分法研究了这些患者的 sNfL 水平与皮肤炎症和抓痕损伤严重程度之间的关系。结果显示观察发现，sNfL 水平与 SISL 评分所测量的皮肤炎症和抓痕损伤严重程度呈正相关（Spearman's rho = 0.70，p = 0.031）。当单独相关时，"仅皮肤炎症 "和 "仅划痕病变 "评分与 sNfL 水平呈正相关（分别为 Spearman's rho = 0.68，p = 0.031；Spearman's rho = 0.66，p = 0.041）。结论：sNfL 可能是与皮肤炎症和/或搔抓相关的皮肤神经损伤的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.