Synthesis and Antioxidant Activity of New Bis-1,3,4-oxadiazoles, Bis-1,3,4-thiadiazoles, and Their Derivatives

Abstract

Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers have been synthesized. The pharmacophore electron-deficient groups (carboxylic, nitrile) have been introduced into the molecule to increase their hydrophilicity and potential biological activity. Functionalized compounds have demonstrated a new type of biological activity, i.e., inhibition of lipid oxidation revealed as a decrease in the amount of MDA.