B cell heterogeneity in cancer comes of age

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-10-14 DOI:10.1016/j.ccell.2024.09.013

Colleen Sturdevant, Yuliya Pylayeva-Gupta

引用次数: 0

Abstract

The role of B cells in cancer remains incompletely understood. Three recent publications, including a study by Fitzsimons et al. in this issue of Cancer Cell,¹ use single-cell RNA sequencing to define pan-cancer atlases of tumor-infiltrating B cell subsets, paving the way for profound advances in our understanding of B cell-dependent antitumor immunity.

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癌症中的 B 细胞异质性时代来临

人们对 B 细胞在癌症中的作用仍然知之甚少。最近发表的三篇论文，包括 Fitzsimons 等人在本期《癌细胞》（Cancer Cell）1 上发表的一项研究，利用单细胞 RNA 测序确定了肿瘤浸润 B 细胞亚群的泛癌症图谱，为我们深入了解 B 细胞依赖性抗肿瘤免疫铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.