Cáncer de mama en el varón: estudio multicéntrico en Aragón durante 27 años

IF 1.3 4区医学 Q3 SURGERY

Cirugia Espanola Pub Date : 2024-10-01 DOI:10.1016/j.ciresp.2024.07.008

Olga Dobato Portoles , Daniel Aparicio Lopez , Reyes Ibañez Carreras , Elena Aguirre Ortega , Beatriz Eizaguirre Zarza , Carmen García Mur , Aurora Carrasquer Puyal , María Pilar Cebollero Benito , Laura Isabel Comín Novella , Marta Allue Cabañuz , Fernando Martinez Ubieto , Ramón Sousa Domínguez , Javier Torcal Aznar , Carmen Casamayor Franco

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Abstract

Introduction

Male breast cancer accounts for 1% of all breast cancers. Its low frequency leads to a lack of awareness, resulting in significant diagnostic delays. Additionally, this limits the available evidence, which primarily uses diagnostic-therapeutic algorithms based on women.

Methods

A multicenter, observational, descriptive, retrospective study was conducted in the autonomous community of Aragon, Spain, from 1995 to 2022 including men with a pathological diagnosis of breast cancer. The prevalence, clinical presentation, pathological characteristics and prognosis of this pathology in men were analyzed.

Results

A total of 148 patients were included, one of the largest series available, with a prevalence of 1%. The most common clinical presentation was a palpable retroareolar mass. Invasive ductal carcinoma was the most frequent type (88.89%), and luminal B was the predominant subtype (47.76%). Surgery was the most utilized treatment; mastectomy was performed in 90.34% and AL in 46.89%. At diagnosis, 52.46% had extramammary involvement. The recurrence rate was 24.1%, and the mortality attributed to the disease was 14.6%.

Conclusions

There is a high rate of metastatic involvement at diagnosis, a high percentage of mutilating surgeries, and a high number of recurrences compared to available studies on males. Additionally, a worse prognosis is observed compared to breast cancer in women, despite these tumors having a less aggressive molecular subtype. These findings highlight the importance of conducting studies focused on men to develop specific protocols.

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男性乳腺癌：阿拉贡 27 年多中心研究

导言：男性乳腺癌占所有乳腺癌的 1%。由于发病率低，人们对其缺乏认识，导致诊断严重延误。从 1995 年到 2022 年，西班牙阿拉贡自治区开展了一项多中心、观察性、描述性和回顾性研究，研究对象包括病理诊断为乳腺癌的男性。研究对男性乳腺癌的发病率、临床表现、病理特征和预后进行了分析。结果共纳入 148 名患者，是目前规模最大的系列研究之一，发病率为 1%。最常见的临床表现是可扪及的乳晕后肿块。浸润性导管癌是最常见的类型（88.89%），管腔 B 是最主要的亚型（47.76%）。手术是最常用的治疗方法；90.34%的患者接受了乳房切除术，46.89%的患者接受了AL术。确诊时，52.46%的患者有乳腺外受累。复发率为 24.1%，死亡率为 14.6%。结论与现有的男性研究相比，乳腺癌的诊断转移率高，切除手术比例高，复发率高。此外，与女性乳腺癌相比，尽管这些肿瘤的分子亚型侵袭性较低，但预后较差。这些发现凸显了开展以男性为重点的研究以制定特定方案的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Espanola SURGERY-

CiteScore

1.20

自引率

21.10%

发文量

173

审稿时长

53 days

期刊介绍： Cirugía Española, an official body of the Asociación Española de Cirujanos (Spanish Association of Surgeons), will consider original articles, reviews, editorials, special articles, scientific letters, letters to the editor, and medical images for publication; all of these will be submitted to an anonymous external peer review process. There is also the possibility of accepting book reviews of recent publications related to General and Digestive Surgery.