Brushite Boron Cement with Antibacterial Properties

IF 0.5 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Inorganic Materials: Applied Research Pub Date : 2024-10-09 DOI:10.1134/S2075113324700928

I. V. Fadeeva, Shachnoza Fuzailova, I. V. Dudenkov, P. V. Slukin, N. A. Andreeva, A. V. Knot’ko, D. V. Deyneko

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Abstract

Boron-containing brushite cements (B-BCs) for bone grafting based on boron-substituted β-tricalcium phosphate (B-TCP) are developed. The phase composition and microstructure of B-BCs are studied. It is shown that the crystalline phase of brushite is formed as a result of hardening of the cements. The behavior of B-BCs in a physiological saline containing a TRIS buffer is studied. The compression strength of B-BCs within 5 days after blending is 22.5 ± 1 MPa. Studies of antibacterial activity against the E. coli gram-negative strain ATCC25922 and S. aureus gram-positive strain ATCC25923 show that boron-containing brushite cement exhibits antibacterial activity against both strains, causing a decrease in the number of colony forming units (CFUs) already after 3 h of incubation. In vitro studies of the developed B-BCs are carried out, and it is shown that the developed cements based on TCP and B-TCP are biocompatible and promising for use in bone tissue surgery.

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具有抗菌性能的刷石硼水泥

以硼取代的β-磷酸三钙（B-TCP）为基础，开发了用于植骨的含硼刷状石水门汀（B-BCs）。研究了 B-BCs 的相组成和微观结构。结果表明，刷石结晶相是在水门汀硬化过程中形成的。研究了 B-BC 在含有 TRIS 缓冲液的生理盐水中的行为。混合后 5 天内 B-BCs 的压缩强度为 22.5 ± 1 兆帕。对大肠杆菌革兰氏阴性菌株 ATCC25922 和金黄色葡萄球菌革兰氏阳性菌株 ATCC25923 的抗菌活性研究表明，含硼的刷状石水泥对这两种菌株都具有抗菌活性，在培养 3 小时后，菌落形成单位（CFU）的数量就会减少。对所开发的 B-BC 进行了体外研究，结果表明所开发的基于 TCP 和 B-TCP 的水门汀具有生物相容性，有望用于骨组织手术。

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来源期刊

Inorganic Materials: Applied Research Engineering-Engineering (all)

CiteScore

0.90

自引率

0.00%

发文量

199

期刊介绍： Inorganic Materials: Applied Research contains translations of research articles devoted to applied aspects of inorganic materials. Best articles are selected from four Russian periodicals: Materialovedenie, Perspektivnye Materialy, Fizika i Khimiya Obrabotki Materialov, and Voprosy Materialovedeniya and translated into English. The journal reports recent achievements in materials science: physical and chemical bases of materials science; effects of synergism in composite materials; computer simulations; creation of new materials (including carbon-based materials and ceramics, semiconductors, superconductors, composite materials, polymers, materials for nuclear engineering, materials for aircraft and space engineering, materials for quantum electronics, materials for electronics and optoelectronics, materials for nuclear and thermonuclear power engineering, radiation-hardened materials, materials for use in medicine, etc.); analytical techniques; structure–property relationships; nanostructures and nanotechnologies; advanced technologies; use of hydrogen in structural materials; and economic and environmental issues. The journal also considers engineering issues of materials processing with plasma, high-gradient crystallization, laser technology, and ultrasonic technology. Currently the journal does not accept direct submissions, but submissions to one of the source journals is possible.