L-Proline Catalyzed Synthesis of Dihydropyrano[2,3-c]pyrazoles and Their Anti-Inflammatory Activity

Abstract

Objective: In the present work synthesis and characterization of new heterocyclic derivatives containing dihydropyrano[2,3-c]pyrazoles. Methods: Synthesis of compounds was done using the conventional method via multicomponent reaction using substituted aldehyde, hydrazine hydrate or phenyl hydrazine, malononitrile, and L-proline as a catalyst with good yield. Reaction optimization is also performed. Results and Discussion: All synthesized compounds were tested for their in vitro anti-inflammatory and a comparison was done against the standard drug Diclofenac sodium. Conclusions: Some of the newly synthesized compounds demonstrated good to moderate anti-inflammatory activity.