{"title":"Construction of a novel fluorescent nanoenzyme based on lanthanides for tumor theranostics","authors":"Lijun Xiang, Chengying Wang, Yifu Mao, Wenjing Li, Yong Jiang, Zhu Huang, Zhifeng Hu, Yong Wang","doi":"10.1007/s11706-024-0698-4","DOIUrl":null,"url":null,"abstract":"<div><p>Traditional lanthanide fluorides lack therapeutic efficacy against tumors, thus limiting their applications in biomedicine. In this study, we introduce a groundbreaking lanthanide-based nanomaterial known as ligand-free Ba<sub>1.4</sub>Mn<sub>0.6</sub>LuF<sub>7</sub>:Yb<sup>3+</sup>/Er<sup>3+</sup>/Ho<sup>3+</sup> (abbreviated as BMLF). This innovative material allows for the simultaneous tuning of upconversion luminescence emissions and Fenton-like reactions through the controlled release of Mn ions within the tumor microenvironment. BMLF exhibits dual functionality through integrating ratiometric fluorescence imaging for diagnosis and nanozyme-based catalytic therapy. These capabilities are successfully harnessed for tumor theranostics <i>in vivo</i>. This research presents a novel approach to leveraging lanthanide fluoride nanomaterials, transforming them into fluorescent nanoenzymes with theranostic potential.</p></div>","PeriodicalId":572,"journal":{"name":"Frontiers of Materials Science","volume":"18 4","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers of Materials Science","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11706-024-0698-4","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Traditional lanthanide fluorides lack therapeutic efficacy against tumors, thus limiting their applications in biomedicine. In this study, we introduce a groundbreaking lanthanide-based nanomaterial known as ligand-free Ba1.4Mn0.6LuF7:Yb3+/Er3+/Ho3+ (abbreviated as BMLF). This innovative material allows for the simultaneous tuning of upconversion luminescence emissions and Fenton-like reactions through the controlled release of Mn ions within the tumor microenvironment. BMLF exhibits dual functionality through integrating ratiometric fluorescence imaging for diagnosis and nanozyme-based catalytic therapy. These capabilities are successfully harnessed for tumor theranostics in vivo. This research presents a novel approach to leveraging lanthanide fluoride nanomaterials, transforming them into fluorescent nanoenzymes with theranostic potential.
期刊介绍：
Frontiers of Materials Science is a peer-reviewed international journal that publishes high quality reviews/mini-reviews, full-length research papers, and short Communications recording the latest pioneering studies on all aspects of materials science. It aims at providing a forum to promote communication and exchange between scientists in the worldwide materials science community.
The subjects are seen from international and interdisciplinary perspectives covering areas including (but not limited to):
Biomaterials including biomimetics and biomineralization;
Nano materials;
Polymers and composites;
New metallic materials;
Advanced ceramics;
Materials modeling and computation;
Frontier materials synthesis and characterization;
Novel methods for materials manufacturing;
Materials performance;
Materials applications in energy, information and biotechnology.
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