An antigen discovery pipeline integrates multi-omics data and informs immunotherapy

IF 33.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Nature biotechnology Pub Date : 2024-10-11 DOI:10.1038/s41587-024-02427-5

引用次数: 0

Abstract

We developed NeoDisc, a computational antigen discovery pipeline that integrates multi-omics data, including genomics, transcriptomics and mass spectrometry-based immunopeptidomics. NeoDisc accurately identifies and prioritizes tumor-specific antigens and designs personalized cancer vaccines. The pipeline reveals tumor heterogeneity and emphasizes defects in antigen presentation that might affect the success of cancer immunotherapy.

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抗原发现管道整合了多组学数据并为免疫疗法提供信息

我们开发了一个计算抗原发现管道 NeoDisc，它整合了多组学数据，包括基因组学、转录组学和基于质谱的免疫肽组学。NeoDisc 能准确识别肿瘤特异性抗原并进行优先排序，从而设计出个性化的癌症疫苗。该管道揭示了肿瘤的异质性，并强调了可能影响癌症免疫疗法成功与否的抗原递呈缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature biotechnology 工程技术-生物工程与应用微生物

CiteScore

63.00

自引率

1.70%

发文量

382

审稿时长

3 months

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