The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and Oxidative Stress Biomarkers in High-Fat-Sugar Diet-Fed Rats

IF 3.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Therapeutics Pub Date : 2024-10-04 DOI:10.1155/2024/3833521

Bader Alsuwayt, Neelam Iftikhar, Abdullah Ijaz Hussain, Ashfaq Ahmad, Irsa Zafar, Arifa Khanam, Wen-Nee Tan, Lutfun Nahar, Afaf F. Almuqati, Esraa Mohammad Haji, Ali F. Almutairy, Satyajit D. Sarker

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Abstract

Background: The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD).

Methods: The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed-phase high-performance liquid chromatography (RP-HPLC). Two specific doses of MPT, namely, 250 and 500 mg/kg body weight (BW), were chosen for the study—referred to as MPT-250 and MPT-500, respectively.

Result: The main phenolic acids and flavonoids identified in MPT, with concentrations exceeding 10 mg/100 mL of tea, included catechin, rutin, salicylic acid, gallic acid, sinapic acid, chlorogenic acid, cinnamic acid, and ellagic acid. The total phenolic (TP) and total flavonoid (TF) contents in MPT were measured to be 5.53 and 7.73 mg/g, respectively. Additionally, MPT demonstrated a 57.2% scavenging capacity with 2,2-diphenyl-1-picrylhydrazyl radical. Notably, the administration of a higher dose (MPT-500) showed a significant reduction in body mass index (BMI) and a 51.24% reduction in the rate of increase in BW compared to the HFSD group. The findings indicated that all the treatment groups, that is, orlistat treatment (OT), MPT-250, and MPT-500 groups, experienced reduced levels of serum total cholesterol (TC), triglyceride (TG), and markers of lipoproteins in contrast to the HFSD group. Moreover, MPT helped restore the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH), thereby demonstrating its potential in combating oxidative stress. The MPT-500 group also displayed decreased liver and kidney weights and an improved atherogenic index when compared to the HFSD group.

Conclusion: The results clearly indicate that a high dosage of MPT showed antiobesity activity which was comparable to the same effects produced by the conventional drug orlistat.

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万寿菊茶多酚对高脂高糖饮食大鼠肥胖和氧化应激生物标志物的生物保护作用

研究背景本研究旨在探索富含茶多酚的万寿菊花瓣茶（MPT）在高脂肪-糖饮食（HFSD）大鼠模型中对抗氧化应激和肥胖的潜力：方法：采用传统的煎煮方法制备 MPT，并使用反相高效液相色谱法（RP-HPLC）分析其多酚成分。研究选择了两种特定剂量的 MPT，即 250 毫克/千克体重（BW）和 500 毫克/千克体重（BW），分别称为 MPT-250 和 MPT-500：结果：在 MPT 中鉴定出的主要酚酸和类黄酮（浓度超过 10 毫克/100 毫升茶）包括儿茶素、芦丁、水杨酸、没食子酸、山奈酸、绿原酸、肉桂酸和鞣花酸。测得 MPT 中的总酚（TP）和总黄酮（TF）含量分别为 5.53 和 7.73 毫克/克。此外，MPT 对 2,2-二苯基-1-苦基肼自由基的清除能力为 57.2%。值得注意的是，与高剂量组（HFSD）相比，服用高剂量组（MPT-500）的体重指数（BMI）显著降低，体重增长率降低了 51.24%。研究结果表明，与 HFSD 组相比，所有治疗组，即奥利司他治疗组（OT）、MPT-250 组和 MPT-500 组的血清总胆固醇（TC）、甘油三酯（TG）和脂蛋白标记物水平均有所降低。此外，MPT 还有助于恢复丙二醛 (MDA)、超氧化物歧化酶 (SOD) 和还原型谷胱甘肽 (GSH) 的水平，从而证明了它在对抗氧化应激方面的潜力。与 HFSD 组相比，MPT-500 组的肝脏和肾脏重量减轻，动脉粥样硬化指数提高：结论：研究结果清楚地表明，高剂量 MPT 具有抗肥胖活性，其效果与传统药物奥利司他不相上下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Therapeutics 医学-心血管系统

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged. Subject areas include (but are by no means limited to): Acute coronary syndrome Arrhythmias Atherosclerosis Basic cardiac electrophysiology Cardiac catheterization Cardiac remodeling Coagulation and thrombosis Diabetic cardiovascular disease Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF) Hyperlipidemia Hypertension Ischemic heart disease Vascular biology Ventricular assist devices Molecular cardio-biology Myocardial regeneration Lipoprotein metabolism Radial artery access Percutaneous coronary intervention Transcatheter aortic and mitral valve replacement.