Outcomes of Left Atrioventricular Valve Operation following Atrioventricular Septal Defect Repair.

IF 4.9 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Thoracic and Cardiovascular Surgery Pub Date : 2024-10-08 DOI:10.1016/j.jtcvs.2024.09.051

Alison J Howell, Devin Chetan, Alvise Guariento, Areeba Zubair, Claudia Almeida, Marisha McClean, Lynne E Nield, Luc Mertens, Chun-Po Steve Fan, David Barron, Osami Honjo

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引用次数: 0

Abstract

Objectives: Left atrioventricular valve (LAVV) operation following repair of atrioventricular septal defects (AVSD) can be challenging. We sought to describe characteristics and outcomes of patients requiring LAVV operation.

Methods: Retrospective review of AVSDs requiring LAVV operation between 2000-2020. Patients who experienced adverse events (AEs; defined as the need for a LAVV reoperation (repair or replacement) or death) were compared to patients without AEs. Freedom from adverse events was displayed using the Kaplan-Meier method. Reoperation and death were characterized in terms of cumulative incidence function, estimated using competing risk models.

Results: Of 843 patients with AVSD repaired, 59 (7.3%) required a LAVV operation and 7 (9%) valve replacement. A simple repair (cleft closure and/or annuloplasty) occurred in 26 (48.1%) and complex repair using multiple techniques in 28 (51.8%) cases. Eleven patients (20%) required further LAVV reoperation; 3 replacement of mechanical valve, 6 new valve replacement (2 Melody, 4 Mechanical) and 2 re-repair. The cumulative incidence of freedom from AE was 84.1% (75.0%, 94.2%), 78.3% (68.2%, 90.0%), 73.4% (62.2%, 86.7%), 69.7% (57.5%, 84.7%) at 1, 5, 10 and 15 years respectively. Cox univariable regression showed smaller weight (p=0.027) and early need for LAVV operation (p=0.02) were associated with AEs while cleft closure (p = 0.003) was protective against AEs. The estimated cumulative incidence of reoperation was higher in complex repairs (17.3% (7.8%, 38.7%) vs 0.5% (NA, NA) at 1 year. Greys p = 0.02). In a comparison of eras (2000-2009, 2010- 2020) there was no difference in AE (Greys p = 0.96).

Conclusions: Adverse outcomes following LAVV reoperation remain common. Smaller infants, those requiring earlier reoperation and complex type repairs are at highest risk. Future studies should focus on which high risk LAVVs are more suited to early LAVV replacement.

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房室隔缺损修复术后左房室瓣手术的疗效。

目的：修复房室间隔缺损（AVDS）后的左房室瓣（LAVV）手术可能具有挑战性。我们试图描述需要进行 LAVV 手术的患者的特征和预后：方法：回顾性分析 2000-2020 年间需要进行 LAVV 手术的 AVSD 患者。将发生不良事件（AE，定义为需要再次进行 LAVV 手术（修复或置换）或死亡）的患者与未发生不良事件的患者进行比较。不良事件发生率采用 Kaplan-Meier 法显示。再手术和死亡的特征是累积发生率函数，使用竞争风险模型进行估算：在 843 名接受过 AVSD 修复的患者中，59 人（7.3%）需要进行 LAVV 手术，7 人（9%）需要进行瓣膜置换术。26例（48.1%）进行了简单修复（裂隙闭合和/或瓣环成形术），28例（51.8%）使用多种技术进行了复杂修复。11名患者（20%）需要再次进行LAVV手术；其中3人更换了机械瓣膜，6人更换了新瓣膜（2人更换了美乐家瓣膜，4人更换了机械瓣膜），2人进行了重新修复。1年、5年、10年和15年的无AE累积发生率分别为84.1%（75.0%，94.2%）、78.3%（68.2%，90.0%）、73.4%（62.2%，86.7%）、69.7%（57.5%，84.7%）。Cox 单变量回归显示，较小的体重（p=0.027）和较早需要进行 LAVV 手术（p=0.02）与 AEs 相关，而裂隙闭合（p=0.003）对 AEs 有保护作用。在复杂修复术中，1 年后再次手术的估计累积发生率较高（17.3% (7.8%, 38.7%) vs 0.5% (NA, NA)。P=0.02）。在年代比较（2000-2009年，2010-2020年）中，AE没有差异（Greys p = 0.96）：结论：LAVV 再次手术后的不良后果仍然很常见。结论：LAVV再手术后的不良后果仍很常见，体型较小的婴儿、需要尽早再手术的婴儿和复杂类型修复的婴儿风险最高。未来的研究应重点关注哪些高风险LAVV更适合早期LAVV置换。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Thoracic and Cardiovascular Surgery 医学-呼吸系统

CiteScore

11.20

自引率

10.00%

发文量

1079

审稿时长

68 days

期刊介绍： The Journal of Thoracic and Cardiovascular Surgery presents original, peer-reviewed articles on diseases of the heart, great vessels, lungs and thorax with emphasis on surgical interventions. An official publication of The American Association for Thoracic Surgery and The Western Thoracic Surgical Association, the Journal focuses on techniques and developments in acquired cardiac surgery, congenital cardiac repair, thoracic procedures, heart and lung transplantation, mechanical circulatory support and other procedures.