DOT1L: orchestrating methylation-dependent radiotheRAPy responses via BRCA1.

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI:10.1016/j.tips.2024.09.008

Justin W Leung, Kyle M Miller

引用次数: 0

Abstract

Breast Cancer Type 1 Susceptibility Protein (BRCA)-1 existing in several functionally distinct complexes, promotes DNA repair of DNA double-strand breaks (DSBs). A recent study by Tang and colleagues identifies the lysine methyltransferase Disruptor of Telomeric Silencing 1-Like (DOT1L) involved in modifying Receptor-Associated Protein 80 (RAP80) to promote BRCA1-A complex localization and repair functions at DNA breaks. This study illuminates a potential therapeutic target for cancer radiotherapy.

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DOT1L：通过 BRCA1 协调甲基化依赖性放射反应。

乳腺癌 1 型易感蛋白（BRCA）-1 存在于多个功能不同的复合物中，可促进 DNA 双链断裂（DSB）的 DNA 修复。Tang及其同事最近的一项研究发现，赖氨酸甲基转移酶Disruptor of Telomeric Silencing 1-Like (DOT1L)参与修饰受体相关蛋白80 (RAP80)，以促进BRCA1-A复合物定位和DNA断裂修复功能。这项研究为癌症放射治疗提供了一个潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.