Comprehensive quality evaluation of dried boletus slices based on fingerprinting and chemometrics

IF 3.1 3区医学 Q2 CHEMISTRY, ANALYTICAL

Journal of pharmaceutical and biomedical analysis Pub Date : 2024-10-06 DOI:10.1016/j.jpba.2024.116505

Zhiyi Ji , Honggao Liu , Jieqing Li , Yuanzhong Wang

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引用次数: 0

Abstract

Mushrooms not only serve as a source of a wide range of nutrients in the structure of the human diet, but they have also received a great deal of attention in the field of biopharmaceuticals because of their wide range of medicinal benefits. Rapid quality certification of boletus (porcini) mushrooms is particularly important as a health food and as a potential source of medicines before purchase and production. Infrared (IR) spectroscopy is commonly used for rapid qualitative and quantitative analyses of foods and herbs. The Ultra Performance Liquid Chromatography (UPLC) combined with systematic fingerprinting quantification was used to analyze the quality consistency of Boletus edulis (B. edulis) from different geographic sources, and a method based on Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy combined with chemometrics for origin traceability and rapid prediction of nucleoside quality marker content of B. edulis dried slices was developed with the aim of achieving rapid, lossless, high-throughput and green quality authentication of raw materials for pharmaceutical products.

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基于指纹图谱和化学计量学的牛肝菌干片综合质量评价。

蘑菇不仅是人类饮食结构中多种营养物质的来源，还因其广泛的药用价值而在生物制药领域备受关注。牛肝菌作为一种健康食品和潜在的药物来源，在采购和生产前对其进行快速质量认证尤为重要。红外（IR）光谱通常用于食品和药材的快速定性和定量分析。本研究采用超高效液相色谱法（UPLC）结合系统指纹定量法分析不同地理来源的牛肝菌（B. edulis）的质量一致性，并采用衰减全反射傅立叶变换红外光谱法（ATR-FTIR）结合化学计量学法进行产地溯源，快速预测牛肝菌（B. edulis）干片中核苷质量标记物的含量。本研究开发了一种基于衰减全反射傅立叶变换红外光谱（ATR-FTIR）并结合化学计量学的方法，用于溯源和快速预测蚕豆干切片中核苷质量标记物的含量，旨在实现快速、无损、高通量和绿色的药品原料质量认证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmaceutical and biomedical analysis 医学-分析化学

CiteScore

6.70

自引率

5.90%

发文量

588

审稿时长

37 days

期刊介绍： This journal is an international medium directed towards the needs of academic, clinical, government and industrial analysis by publishing original research reports and critical reviews on pharmaceutical and biomedical analysis. It covers the interdisciplinary aspects of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. Submissions on novel applications focusing on drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling; drug-related aspects of analytical biochemistry and forensic toxicology; quality assurance in the pharmaceutical industry are also welcome. Studies from areas of well established and poorly selective methods, such as UV-VIS spectrophotometry (including derivative and multi-wavelength measurements), basic electroanalytical (potentiometric, polarographic and voltammetric) methods, fluorimetry, flow-injection analysis, etc. are accepted for publication in exceptional cases only, if a unique and substantial advantage over presently known systems is demonstrated. The same applies to the assay of simple drug formulations by any kind of methods and the determination of drugs in biological samples based merely on spiked samples. Drug purity/stability studies should contain information on the structure elucidation of the impurities/degradants.