Methotrexate polyglutamates.

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Expert Review of Clinical Pharmacology Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI:10.1080/17512433.2024.2416674

Zhilin Yang, Jiayi Mo, Wenshu Li, Zhigang Zhao, Shenghui Mei

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引用次数: 0

Abstract

Introduction: Methotrexate polyglutamates (MTXPGs) are intracellular metabolites of methotrexate (MTX) that play a critical role in the drug's activity, influencing both its efficacy and toxicity. As the exact implications of MTXPGs in these processes remain a subject of debate, a comprehensive review of MTXPGs could provide valuable insights for clinicians and pharmacists, potentially minimizing adverse reactions and enhancing therapeutic outcomes.

Areas covered: A comprehensive search of relevant literature was conducted in PubMed and Web of Science databases, including studies from their inception to April 2024. Eligible studies included reviews, clinical trials, and real-world analyses. Additional manual searches and citation reviews were also performed. This review aims to explore MTXPGs with a primary focus on their pharmacokinetics, analytical methods, determinants of drug exposure, and their correlation with MTX efficacy and toxicity.

Expert opinion: MTXPGs have not yet garnered significant attention in clinical practice. However, multiple studies have demonstrated a relationship between MTXPGs and the efficacy and toxicity of MTX, suggesting a potential avenue for personalized treatment strategies. Future research should aim to further validate and refine this correlation. Additionally, attention should also be directed toward other metabolites of MTX, which may hold clinical significance.

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甲氨蝶呤多聚谷氨酸盐。

简介：甲氨蝶呤多聚谷氨酸盐（MTXPGs）是甲氨蝶呤（MTX）的细胞内代谢产物，在药物活性中起着至关重要的作用，影响着药物的疗效和毒性。由于 MTXPGs 在这些过程中的确切影响仍存在争议，因此对 MTXPGs 进行全面审查可为临床医生和药剂师提供有价值的见解，从而有可能最大限度地减少不良反应并提高治疗效果：在 PubMed 和 Web of Science 数据库中对相关文献进行了全面检索，包括从开始到 2024 年 4 月的研究。符合条件的研究包括综述、临床试验和真实世界分析。此外，还进行了其他人工检索和引文综述。本综述旨在探讨 MTXPGs，主要关注其药代动力学、分析方法、药物暴露的决定因素以及与 MTX 疗效和毒性的相关性：MTXPG尚未在临床实践中引起广泛关注。然而，多项研究表明，MTXPGs 与 MTX 的疗效和毒性之间存在关系，这为个性化治疗策略提供了潜在的途径。未来的研究应旨在进一步验证和完善这种相关性。此外，还应关注 MTX 的其他代谢物，它们可能具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Clinical Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

7.30

自引率

2.30%

发文量

127

期刊介绍： Advances in drug development technologies are yielding innovative new therapies, from potentially lifesaving medicines to lifestyle products. In recent years, however, the cost of developing new drugs has soared, and concerns over drug resistance and pharmacoeconomics have come to the fore. Adverse reactions experienced at the clinical trial level serve as a constant reminder of the importance of rigorous safety and toxicity testing. Furthermore the advent of pharmacogenomics and ‘individualized’ approaches to therapy will demand a fresh approach to drug evaluation and healthcare delivery. Clinical Pharmacology provides an essential role in integrating the expertise of all of the specialists and players who are active in meeting such challenges in modern biomedical practice.