The Construction of Furocoumarins through Iron-Catalyzed Relay Annulation of Oxime Esters with 4-Hydroxycoumarins

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-10-10 DOI:10.1021/acs.orglett.4c03063

Kun Jiang, Qing-Peng Liu, Yu-Qiang Zhou, Ning Yu, Lei Li, Ye Wei

引用次数: 0

Abstract

An iron-catalyzed relay annulation protocol was disclosed, which utilizes oxime esters and 4-hydroxycoumarins as the readily available starting materials and showcases broad substrate scope and good functional group tolerance. This method allows the simultaneous generation of two C–C and one C–O bonds and two rings in one step, affording structurally new furocoumarins in moderate to good yields.

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通过铁催化的肟酯与 4-羟基香豆素的接力嵌合构建呋喃香豆素

该方法利用肟酯和 4-羟基香豆素作为现成的起始原料，具有广泛的底物范围和良好的官能团耐受性。该方法可在一个步骤中同时生成两个 C-C 键和一个 C-O 键以及两个环，从而以中等至良好的产率获得结构上全新的呋喃香豆素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.