{"title":"Pediatric Myelodysplastic Syndrome.","authors":"Zaina Inam, Miao Pan, Yaser Diab, Reuven Schore, Anant Vatsayan, Jinjun Cheng","doi":"10.5858/arpa.2024-0164-RA","DOIUrl":null,"url":null,"abstract":"<p><strong>Context.—: </strong>Myelodysplastic syndromes (MDSs) are rare in children and have unique clinical manifestations and implications.</p><p><strong>Objective.—: </strong>To review the clinical features, pathogenesis, and classification of pediatric MDS.</p><p><strong>Data sources.—: </strong>Published literature and personal experience.</p><p><strong>Conclusions.—: </strong>Pediatric MDS vastly differs from adult MDS. Evaluation for the presence of an underlying germline predisposition syndrome is critical for optimal classification and management. Because of the rarity of cases, resources to aid with the recognition, diagnosis, and management of pediatric MDS are limited, and multi-institutional collaborative studies are needed for the future.</p>","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of pathology & laboratory medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5858/arpa.2024-0164-RA","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Context.—: Myelodysplastic syndromes (MDSs) are rare in children and have unique clinical manifestations and implications.
Objective.—: To review the clinical features, pathogenesis, and classification of pediatric MDS.
Data sources.—: Published literature and personal experience.
Conclusions.—: Pediatric MDS vastly differs from adult MDS. Evaluation for the presence of an underlying germline predisposition syndrome is critical for optimal classification and management. Because of the rarity of cases, resources to aid with the recognition, diagnosis, and management of pediatric MDS are limited, and multi-institutional collaborative studies are needed for the future.
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