PREGABALIN AS A PREOPERATIVE ADJUVANT IN PATIENTS WITH CARPAL TUNNEL SYNDROME.

IF 0.5 4区医学 Q4 ORTHOPEDICS

Acta Ortopedica Brasileira Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.1590/1413-785220243204e278895

Fábio Hideki Nishi Eto, Thiago Broggin Dutra Rodrigues, Victor Elzio Gasperoni Matias, Yussef Ali Abdouni

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引用次数: 0

Abstract

Objective: To evaluate the pregabalin adjuvant effect in patients with carpal tunnel syndrome (CTS) surgically treated, analyzing postoperative pain and the incidence of complex regional pain syndrome (CRPS).

Methods: Outpatient surgical candidates with CTS were selected and followed for 12 months, divided into three groups. The Control Group received a placebo, the Pregabalin 75mg Group received a daily dose, and the Pregabalin 150mg Group received a daily dose of the medication. Patient progress was evaluated using the visual analog scale (VAS) for pain and the DN4 neuropathic pain score before surgery, one month and three months after.

Results: The administration of pregabalin to surgical patients with CTS did not demonstrate significant differences in immediate postoperative pain relief. Additionally, there were no statistically significant variations in the incidence of complications, such as CRPS, among the groups.

Conclusion: This study did not show a significant impact of pregabalin on postoperative pain relief or the reduction of CRPS incidence in patients undergoing surgery for CTS. These results suggest that pregabalin might not be an effective adjuvant in these surgical situations. Level of evidence II (Oxford), Prospective Comparative Study.

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普瑞巴林作为腕管综合征患者的术前辅助用药。

目的评估普瑞巴林对接受手术治疗的腕管综合征（CTS）患者的辅助效果，分析术后疼痛和复杂区域疼痛综合征（CRPS）的发生率：方法：选取门诊手术治疗的 CTS 患者，将其分为三组，随访 12 个月。对照组服用安慰剂，普瑞巴林 75 毫克组每日服用一次，普瑞巴林 150 毫克组每日服用一次。在手术前、手术后一个月和三个月，使用疼痛视觉模拟量表（VAS）和 DN4 神经病理性疼痛评分对患者的病情进展进行评估：结果：对患有 CTS 的手术患者使用普瑞巴林后，术后即刻疼痛缓解情况没有明显差异。此外，各组间并发症（如 CRPS）的发生率也没有统计学意义上的显著差异：本研究并未显示普瑞巴林对缓解CTS手术患者的术后疼痛或降低CRPS发病率有明显影响。这些结果表明，普瑞巴林在这些手术中可能不是一种有效的辅助药物。证据级别 II（牛津），前瞻性比较研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.