[Research progress on cardiac arrest-cardiopulmonary resuscitation model in rats].

Abstract

The animal model of cardiac arrest-cardiopulmonary resuscitation (CA-CPR) is the cornerstone of resuscitation research, serving as a tool to address adverse outcomes after cardiac arrest (CA). However, due to the different causes of CA, the pathophysiological changes of CA are not identical. Therefore, the preparation of similar animal models for different types of CA is the basis for studying the pathophysiological changes of CA. Rats are favored by researchers because of their low experimental cost, easy operation, and similar hemodynamic parameters and pathophysiological changes during resuscitation. This paper reviewed the common methods of animal models of CA-CPR in rats. In this review, the methods, criteria, advantages, disadvantages and precautions of each model were analyzed, which would provide useful reference for cardiopulmonary resuscitation (CPR) researchers.