Do professional painters comprise a high risk group for genotoxicity? A systematic review.

IF 3.2 4区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Toxicology Mechanisms and Methods Pub Date : 2024-10-09 DOI:10.1080/15376516.2024.2411060

Thiago Guedes Pinto, Thayza Aires Dias, Daniel Araki Ribeiro

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Abstract

Professional painters represent an occupational population group that deserves attention for study in the field of occupational toxicology due to the wide range of complex chemical mixtures they are exposed to. It is imperative to underscore that the International Agency for Research on Cancer has classified commercial painting as a high-risk occupation for the development of cancer. Given this context, the primary objective of the present study was to conduct a systematic review aimed at addressing the following question: are car painters at occupational risk regarding potential genotoxicity? To address this question, a selection process was undertaken, with three reviewers carefully selecting, reading, and analyzing full manuscripts from 26 studies included in this review. The technical rigor of these studies underwent meticulous scrutiny, culminating in the classification of six studies as Strong, eight as Moderate, and 12 as Weak, predicated on the extent of confounders considered. Taken together, the findings suggest that chemical substances from paints may indeed pose a risk of genotoxicity for professionals in this field, as all studies indicated genotoxicity among professional painters through various tests.

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职业油漆工是遗传毒性的高危人群吗？系统综述。

职业油漆工是一个值得职业毒理学研究关注的职业人群，因为他们会接触到各种复杂的化学混合物。必须强调的是，国际癌症研究机构已将商业油漆工列为罹患癌症的高危职业。有鉴于此，本研究的主要目的是进行系统综述，以解决以下问题：汽车油漆工是否存在潜在的遗传毒性职业风险？为了解决这个问题，我们进行了一个筛选过程，由三位审稿人仔细挑选、阅读和分析了纳入本综述的 26 项研究的完整手稿。对这些研究的技术严谨性进行了细致的审查，最终根据所考虑的混杂因素的程度，将 6 项研究划分为 "强"、8 项为 "中"、12 项为 "弱"。综上所述，研究结果表明，油漆中的化学物质确实可能会对该领域的专业人员造成基因毒性风险，因为所有研究都通过各种测试表明了专业油漆工的基因毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicology Mechanisms and Methods 医学-毒理学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.