The dosimetric accuracy of a commercial model-based dose calculation algorithm in modeling a six-groove direction modulated brachytherapy tandem applicator.
{"title":"The dosimetric accuracy of a commercial model-based dose calculation algorithm in modeling a six-groove direction modulated brachytherapy tandem applicator.","authors":"Moeen Meftahi, William Y Song","doi":"10.1088/1361-6560/ad84b6","DOIUrl":null,"url":null,"abstract":"<p><p><i>Objective.</i>With advancements in high-dose rate brachytherapy, the clinical translation of intensity modulated brachytherapy (IMBT) innovations necessitates utilization of model-based dose calculation algorithms (MBDCA) for accurate and rapid dose calculations. This study uniquely benchmarks a commercial MBDCA, BrachyVision ACUROS<sup>TM</sup>(BVA), against Monte Carlo (MC) simulations, evaluating dose distributions for a novel IMBT applicator, termed as the<i>six-groove</i>Direction Modulated Brachytherapy (DMBT) tandem, expanding beyond previous focus on partially shielded vaginal cylinder applicators, through a novel methodology.<i>Approach.</i>The DMBT tandem applicator, made of a tungsten alloy with six evenly spaced grooves, was simulated using the GEANT4 MC code. Subsequently, two main scenarios were created using the BVA and reproduced by the MC simulations: '<i>Source at the Center of the Water Phantom (SACWP)</i>' and '<i>Source at the Middle of the Applicator (SAMA)</i>' for three cubical virtual water phantoms (20 cm)<sup>3</sup>, (30 cm)<sup>3</sup>, and (40 cm)<sup>3</sup>. A track length estimator was utilized for dose calculation and 2D/3D scoring were performed. The difference in isodose surfaces/lines (i.e. coverage) at each voxel,<i>ΔD</i><sub>Isodose Levels/Lines</sub>, was thus calculated for relevant normalization points (<i>r</i><sub>ref</sub>).<i>Results.</i>The coverage was comparable, based on 2D scoring, between the BVA and MC isodose surfaces/lines for the region of clinical relevance, (i.e. within 5 cm radius from the source) with<i>ΔD</i><sub>Isodose Lines</sub>(<i>r</i><sub>ref</sub>: 1 cm from the source) falling within 2% for the two scenarios for all phantom sizes. For the phantom (20 cm)<sup>3</sup>,<i>ΔD</i><sub>Isodose Levels</sub>(3D scoring) recorded the range [-3.0% +6.5%] ([-7.4% +7.3%]) for 95% of the voxels of the same scoring volume for the SACWP (SAMA) scenario.<i>Significance.</i>The results indicated that the BVA could render comparable coverage as compared to the MC simulations in the region of clinical relevance for different phantom sizes.<i>ΔD</i><sub>Isodose Lines</sub>may offer an advantageous metric for evaluation of MBDCAs in clinical setting.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/ad84b6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective.With advancements in high-dose rate brachytherapy, the clinical translation of intensity modulated brachytherapy (IMBT) innovations necessitates utilization of model-based dose calculation algorithms (MBDCA) for accurate and rapid dose calculations. This study uniquely benchmarks a commercial MBDCA, BrachyVision ACUROSTM(BVA), against Monte Carlo (MC) simulations, evaluating dose distributions for a novel IMBT applicator, termed as thesix-grooveDirection Modulated Brachytherapy (DMBT) tandem, expanding beyond previous focus on partially shielded vaginal cylinder applicators, through a novel methodology.Approach.The DMBT tandem applicator, made of a tungsten alloy with six evenly spaced grooves, was simulated using the GEANT4 MC code. Subsequently, two main scenarios were created using the BVA and reproduced by the MC simulations: 'Source at the Center of the Water Phantom (SACWP)' and 'Source at the Middle of the Applicator (SAMA)' for three cubical virtual water phantoms (20 cm)3, (30 cm)3, and (40 cm)3. A track length estimator was utilized for dose calculation and 2D/3D scoring were performed. The difference in isodose surfaces/lines (i.e. coverage) at each voxel,ΔDIsodose Levels/Lines, was thus calculated for relevant normalization points (rref).Results.The coverage was comparable, based on 2D scoring, between the BVA and MC isodose surfaces/lines for the region of clinical relevance, (i.e. within 5 cm radius from the source) withΔDIsodose Lines(rref: 1 cm from the source) falling within 2% for the two scenarios for all phantom sizes. For the phantom (20 cm)3,ΔDIsodose Levels(3D scoring) recorded the range [-3.0% +6.5%] ([-7.4% +7.3%]) for 95% of the voxels of the same scoring volume for the SACWP (SAMA) scenario.Significance.The results indicated that the BVA could render comparable coverage as compared to the MC simulations in the region of clinical relevance for different phantom sizes.ΔDIsodose Linesmay offer an advantageous metric for evaluation of MBDCAs in clinical setting.
期刊介绍：
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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