Passive Anti-amyloid Beta Monoclonal Antibodies: Lessons Learned over Past 20 Years.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI:10.1007/s40120-024-00664-z

Alexandra Wicker, Jahnavi Shriram, Boris Decourt, Marwan Noel Sabbagh

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that significantly impairs cognitive and functional abilities, placing a substantial burden on both patients and caregivers. Current symptomatic treatments fail to halt the progression of AD, highlighting the urgent need for more effective disease-modifying therapies (DMTs). DMTs under development are classified as either passive or active on the basis of their mechanisms of eliciting an immune response. While this review will touch on active immunotherapies, we primarily focus on anti-amyloid beta monoclonal antibodies (mAbs), a form of passive immunotherapy, discussing their multifaceted role in AD treatment and the critical factors influencing their therapeutic efficacy. With two mAbs now approved and prescribed in the clinical setting, it is crucial to reflect on the lessons learned from trials of earlier mAbs that have shaped their development and contributed to their current success. These insights can then guide the creation of even more effective mAbs, ultimately enhancing therapeutic outcomes for patients with AD while minimizing adverse events.

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被动抗淀粉样蛋白 Beta 单克隆抗体：过去 20 年的经验教训。

阿尔茨海默病（AD）是一种神经退行性疾病，严重损害患者的认知能力和功能，给患者和护理人员带来沉重负担。目前的对症治疗无法阻止阿尔茨海默病的发展，因此迫切需要更有效的疾病改变疗法（DMT）。正在开发的 DMT 根据其诱发免疫反应的机制分为被动型和主动型。虽然本综述将涉及主动免疫疗法，但我们主要关注抗淀粉样蛋白β单克隆抗体（mAbs）这种被动免疫疗法，讨论它们在AD治疗中的多方面作用以及影响其疗效的关键因素。目前有两种 mAbs 已被批准并用于临床，因此反思从早期 mAbs 试验中汲取的经验教训至关重要，这些经验教训影响了它们的发展并促成了它们目前的成功。这些经验可以指导开发更有效的 mAbs，最终提高 AD 患者的治疗效果，同时最大限度地减少不良反应。

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

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