Diagnostic and prognostic significance of serum lncRNA MBNL1-AS1 expression in patients with atherosclerosis.

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Minerva cardiology and angiology Pub Date : 2024-10-08 DOI:10.23736/S2724-5683.24.06648-1

Zhao Wang, Liang Cheng, Zhengjie Zhao, Honglei Chen, Junzhi Wang, Jiafeng Niu, Youpei Wang, Xiaoge Zhang

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引用次数: 0

Abstract

Background: Atherosclerosis (AS) is the pathological basis of many cardiovascular and cerebrovascular diseases. To further the investigation of treatments for AS, this research analyzed the role of lncRNA MBNL1-AS1.

Methods: MBNL1-AS1 expression in the serum of AS patients and healthy controls were detected by qPCR. Its diagnostic value in AS was assessed by receiver operating characteristic curve (ROC). Additionally, the link between MBNL1-AS1, carotid intima-media thickness (CIMT) and C-reactive protein (CRP) was examined using the Spearman correlation coefficient. The prognostic value of MBNL1-AS1 in AS was assessed using the Kaplan-Meier survival curve and univariate and multivariate Cox regression analysis.

Results: The present study consisted of 103 patients with AS and 92 healthy patients (HC) and comparison of baseline data between the two groups revealed no remarkable difference (P>0.05) except for CRP (P<0.0001). The serum of AS patients exhibited a considerably higher expression of MBNL1-AS1 in comparison to the HC group. Furthermore, MBNL1-AS1 was highly expressed in patients following higher CIMT and CRP values, which was positively linked with both, respectively (r>0.5, P<0.001). Meanwhile. MBNL1-AS1 has enhanced diagnostic accuracy in AS patients (AUC=0.893) and can be utilized as an independent prognostic factor for AS. Patients with high MBNL1-AS1 expression have a higher likelihood of cardiovascular events. (log rang P=0.0025).

Conclusions: Elevated MBNL1-AS1p can be used as a potential marker for the clinical diagnosis of AS and is linked to a poor prognosis of AS.

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动脉粥样硬化患者血清 lncRNA MBNL1-AS1 表达的诊断和预后意义。

背景：动脉粥样硬化（AS动脉粥样硬化（AS）是多种心脑血管疾病的病理基础。为了进一步研究AS的治疗方法，本研究分析了lncRNA MBNL1-AS1的作用：方法：通过qPCR检测强直性脊柱炎患者和健康对照组血清中MBNL1-AS1的表达。方法：通过qPCR检测强直性脊柱炎患者和健康对照组血清中MBNL1-AS1的表达，并通过接收者操作特征曲线（ROC）评估其对强直性脊柱炎的诊断价值。此外，还利用斯皮尔曼相关系数检验了 MBNL1-AS1、颈动脉内膜中层厚度（CIMT）和 C 反应蛋白（CRP）之间的联系。采用 Kaplan-Meier 生存曲线以及单变量和多变量 Cox 回归分析评估了 MBNL1-AS1 在强直性脊柱炎中的预后价值：本研究包括103名强直性脊柱炎患者和92名健康患者（HC），比较两组患者的基线数据发现，除CRP（P0.5，PC结论）外，两组患者无明显差异（P>0.05）：MBNL1-AS1p 升高可作为强直性脊柱炎临床诊断的潜在标志物，并与强直性脊柱炎的不良预后有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Minerva cardiology and angiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

18.80%

发文量

118