The prognostic role of Neurologic Pupil Index in COVID-19 patients: a retrospective study.

IF 2.9 3区医学 Q1 ANESTHESIOLOGY

Minerva anestesiologica Pub Date : 2024-10-01 DOI:10.23736/S0375-9393.24.18074-1

Andrea Garone, Elisa Gouvea Bogossian, Caterina Peratoner, Andrea Minini, Giuseppina Giannì, Ernesto Migliorino, Katia Donadello, Fabio S Taccone, Lorenzo Peluso

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引用次数: 0

Abstract

Background: Neurological complications have been observed in approximately 30% of hospitalized COVID-19 patients. The aim of this study was to evaluate whether early assessment of the Neurological Pupil Index (NPi^TM) derived from an automated pupillometry could predict mortality in critically ill COVID-19 patients.

Methods: Retrospective cohort study of adult critically ill COVID-19 patients admitted to the intensive care unit of a University Hospital; patients without NPi measurement were excluded. The worst NPi (i.e. lowest value from one eye) was collected daily and then computed over the first five days of assessment. Mortality was assessed at hospital discharge. The secondary endpoint involved assessing differences in neurological assessments between patients who developed neurological complications and those who did not.

Results: A total of 217 patients were included over the study period (median age 61 [50-68] years), 70% were males. A total of 97 patients (45%) died during the hospital stay. Among all patients, 35 (16%) experienced neurological complications. Non-survivors showed significantly a lower overall NPi (3.0 [2.0-4.1] vs. 3.4 [2.7-4.2]; P=0.04) than survivors. At multivariate logistic regression NPi was not significantly associated with in-hospital mortality. Moreover, no differences in different NPi measurements were observed between patients with and without neurological complications.

Conclusions: In this study, NPi values were not independent predictor of mortality and neurological complications in critically ill COVID-19 patients.

查看原文本刊更多论文

COVID-19患者神经瞳孔指数的预后作用：一项回顾性研究。

背景：约有 30% 的 COVID-19 住院患者出现神经系统并发症。本研究旨在评估通过自动瞳孔测量仪得出的神经瞳孔指数（NPiTM）的早期评估是否能预测 COVID-19 重症患者的死亡率：对某大学医院重症监护室收治的 COVID-19 成年重症患者进行回顾性队列研究；未进行 NPi 测量的患者被排除在外。每天收集最差的 NPi（即一只眼睛的最低值），然后计算前五天的评估结果。死亡率在出院时进行评估。次要终点包括评估出现神经系统并发症的患者与未出现并发症的患者在神经系统评估方面的差异：研究期间共纳入 217 名患者（中位年龄 61 [50-68] 岁），其中 70% 为男性。共有 97 名患者（45%）在住院期间死亡。所有患者中有 35 人（16%）出现神经系统并发症。非幸存者的总体 NPi 明显低于幸存者（3.0 [2.0-4.1] vs. 3.4 [2.7-4.2]; P=0.04）。在多变量逻辑回归中，NPi 与院内死亡率无明显关联。此外，在有神经系统并发症和无神经系统并发症的患者之间，未观察到不同NPi测量值之间的差异：在这项研究中，NPi值并不能独立预测COVID-19重症患者的死亡率和神经系统并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Minerva anestesiologica 医学-麻醉学

CiteScore

4.50

自引率

21.90%

发文量

367

审稿时长

4-8 weeks

期刊介绍： Minerva Anestesiologica is the journal of the Italian National Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care. Minerva Anestesiologica publishes scientific papers on Anesthesiology, Intensive care, Analgesia, Perioperative Medicine and related fields. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors.