Unveiling the roles of LEMD proteins in cellular processes

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-10-05 DOI:10.1016/j.lfs.2024.123116

引用次数: 0

Abstract

Proteins localized in the inner nuclear membrane (INM) engage in various fundamental cellular processes via their interactions with outer nuclear membrane (ONM) proteins and nuclear lamina. LAP2-emerin-MAN1 domain (LEMD) family proteins, predominantly positioned in the INM, participate in the maintenance of INM functions, including the reconstruction of the nuclear envelope during mitosis, mechanotransduction, and gene transcriptional modulation. Malfunction of LEMD proteins leads to severe tissue-restricted diseases, which may manifest as fatal deformities and defects. In this review, we summarize the significant roles of LEMD proteins in cellular processes, explains the mechanisms of LEMD protein-related diseases, and puts forward questions in less-explored areas like details in tissue-restricted phenotypes. It intends to sort out previous works about LEMD proteins and pave way for future researchers who might discover deeper mechanisms of and better treatment strategies for LEMD protein-related diseases.

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揭示 LEMD 蛋白在细胞过程中的作用。

定位于核内膜（INM）的蛋白质通过与核外膜（ONM）蛋白质和核薄层的相互作用参与各种基本的细胞过程。LAP2-emerin-MAN1结构域（LEMD）家族蛋白主要定位于INM，参与维持INM的功能，包括有丝分裂过程中核包膜的重建、机械传导和基因转录调控。LEMD 蛋白的功能失常会导致严重的组织限制性疾病，可能表现为致命的畸形和缺陷。在这篇综述中，我们总结了LEMD蛋白在细胞过程中的重要作用，解释了LEMD蛋白相关疾病的发生机制，并提出了组织受限表型细节等较少探讨的领域的问题。该报告旨在梳理以往有关LEMD蛋白的研究成果，为未来研究人员发现LEMD蛋白相关疾病的深层机制和更好的治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.