Quantitative MRI biomarker for classification of clinically significant prostate cancer: Calibration for reproducibility across echo times

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Karoline Kallis, Christopher C. Conlin, Courtney Ollison, Michael E. Hahn, Rebecca Rakow-Penner, Anders M. Dale, Tyler M. Seibert
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引用次数: 0

Abstract

Purpose

The purpose of the present study is to develop a calibration method to account for differences in echo times (TE) and facilitate the use of restriction spectrum imaging restriction score (RSIrs) as a quantitative biomarker for the detection of clinically significant prostate cancer (csPCa).

Methods

This study included 197 consecutive patients who underwent MRI and biopsy examination; 97 were diagnosed with csPCa (grade group ≥ 2). RSI data were acquired three times during the same session: twice at minimum TE ~75 ms and once at TE = 90 ms (TEmin1, TEmin2, and TE90, respectively). A linear regression model was determined to match the C-maps of TE90 to the reference C-maps of TEmin1 within the interval ranging from 95th to 99th percentile of signal intensity within the prostate. RSIrs comparisons were made at the 98th percentile within each patient's prostate.

We compared RSIrs from calibrated TE90 (RSIrsTE90corr) and uncorrected TE90 (RSIrsTE90) to RSIrs from reference TEmin1 (RSIrsTEmin1) and repeated TEmin2 (RSIrsTEmin2). Calibration performance was evaluated with sensitivity, specificity and area under the ROC curve (AUC).

Results

Scaling factors for C1, C2, C3, and C4 were estimated as 1.68, 1.33, 1.02, and 1.13, respectively. In non-csPCa cases, the 98th percentile of RSIrsTEmin2 and RSIrsTEmin1 differed by 0.27 ± 0.86SI (mean ± standard deviation), whereas RSIrsTE90 differed from RSIrsTEmin1 by 1.82 ± 1.20SI. After calibration, this bias was reduced to -0.51 ± 1.21SI, representing a 72% reduction in absolute error. For patients with csPCa, the difference was 0.54 ± 1.98SI between RSIrsTEmin2 and RSIrsTEmin1 and 2.28 ± 2.06SI between RSIrsTE90 and RSIrsTEmin1. After calibration, the mean difference decreased to -1.03SI, a 55% reduction in absolute error. At the Youden index for patient-level classification of csPCa (8.94SI), RSIrsTEmin1 has a sensitivity of 66% and a specificity of 72%.

Conclusions

The proposed linear calibration method produces similar quantitative biomarker values for acquisitions with different TE, reducing TE-induced error by 72% and 55% for non-csPCa and csPCa, respectively.

Abstract Image

用于对有临床意义的前列腺癌进行分类的定量 MRI 生物标记物:校准不同回波时间的可重复性。
目的:本研究旨在开发一种校准方法,以考虑回波时间(TE)的差异,并促进限制谱成像限制评分(RSIrs)作为定量生物标志物用于检测具有临床意义的前列腺癌(csPCa):这项研究包括197名接受磁共振成像和活组织检查的连续患者,其中97人被诊断为前列腺癌(等级组≥2)。在同一疗程中采集了三次 RSI 数据:两次在最小 TE ~75 ms 时采集,一次在 TE = 90 ms 时采集(分别为 TEmin1、TEmin2 和 TE90)。确定了一个线性回归模型,以便在前列腺内信号强度的第 95 百分位数到第 99 百分位数区间内,将 TE90 的 C 图与 TEmin1 的参考 C 图进行匹配。在每位患者前列腺内的第 98 个百分位进行 RSIrs 比较。我们将校准 TE90 的 RSIrs(RSIrsTE90corr)和未校准 TE90 的 RSIrs(RSIrsTE90)与参考 TEmin1 的 RSIrs(RSIrsTEmin1)和重复 TEmin2 的 RSIrs(RSIrsTEmin2)进行了比较。校准性能通过灵敏度、特异性和 ROC 曲线下面积(AUC)进行评估:C1、C2、C3 和 C4 的比例因子估计分别为 1.68、1.33、1.02 和 1.13。在非csPCa 病例中,RSIrsTEmin2 和 RSIrsTEmin1 的第 98 百分位数相差 0.27 ± 0.86SI(平均值 ± 标准差),而 RSIrsTE90 与 RSIrsTEmin1 相差 1.82 ± 1.20SI。校准后,这一偏差减少到 -0.51 ± 1.21SI,绝对误差减少了 72%。对于 csPCa 患者,RSIrsTEmin2 和 RSIrsTEmin1 之间的差异为 0.54 ± 1.98SI,RSIrsTE90 和 RSIrsTEmin1 之间的差异为 2.28 ± 2.06SI。校准后,平均差降至-1.03SI,绝对误差减少了 55%。根据 csPCa 患者级别分类的尤登指数(8.94SI),RSIrsTEmin1 的灵敏度为 66%,特异度为 72%:结论:建议的线性校准方法能在不同TE的采集中产生相似的定量生物标志物值,将TE引起的非csPCa和csPCa误差分别降低了72%和55%。
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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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