Associations of Lifestyle, Ambient Air Pollution With Progression of Asthma in Adults: A Comprehensive Analysis of UK Biobank Cohort.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Journal of Public Health Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/ijph.2024.1607640

Jialu He, Jiahui Wu, Yinan He, Dequan Shen, Xianglong Huang, Xinmeng Yao, Weihong Tang, Guo-Bo Chen, Chengyin Ye

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引用次数: 0

Abstract

Objectives: We aim to investigate the associations between lifestyle, ambient air pollution with crucial outcomes in the progression of adult asthma, including asthma new-onset and asthma hospitalisation.

Methods: 176,800 participants were included to assess the prospective association between baseline risk exposures and the subsequent asthma onset, 17,387 participants were used to evaluate asthma hospitalisation. Cox regression models were employed to examine the associations.

Results: In terms of lifestyle factors, the HRs (95% CIs) of the least healthy lifestyle categories for asthma incidence and hospitalization were 1.099 (1.017-1.187) and 1.064 (1.008-1.123), respectively. For pollutants, PM_2.5, especially the traffic-related PM_2.5 component, was consistently recognized as a significant risk factor for asthma onset (HR = 1.064, 95% CI: 1.034-1.094) and hospitalisation (HR = 1.031, 95% CI: 1.010-1.052) under various model adjustments. Low socioeconomic status also played a major role in the progression of adult asthma.

Conclusion: Our study provides crucial insights into factors influencing the progression of adult asthma. Monitoring and reducing exposure to air pollution, particularly PM_2.5, promoting healthier lifestyle, and addressing socioeconomic inequity are important in preventing and managing asthma.

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生活方式、环境空气污染与成人哮喘进展的关系：英国生物库队列综合分析》。

目的：我们旨在研究生活方式、环境空气污染与成人哮喘发展过程中的重要结果（包括哮喘新发和哮喘住院）之间的关系：我们旨在研究生活方式、环境空气污染与成人哮喘发展过程中的重要结果（包括哮喘新发和哮喘住院）之间的关联。方法：纳入 176800 名参与者，评估基线风险暴露与后续哮喘发病之间的前瞻性关联；纳入 17387 名参与者，评估哮喘住院情况。研究采用 Cox 回归模型来检验两者之间的关联：在生活方式因素方面，最不健康的生活方式类别对哮喘发病率和住院率的HRs（95% CIs）分别为1.099（1.017-1.187）和1.064（1.008-1.123）。在污染物方面，PM2.5，尤其是与交通相关的 PM2.5 部分，在各种模型调整下始终被认为是哮喘发病（HR = 1.064，95% CI：1.034-1.094）和住院（HR = 1.031，95% CI：1.010-1.052）的重要风险因素。低社会经济地位在成人哮喘的发展过程中也起到了重要作用：我们的研究为了解影响成人哮喘发展的因素提供了重要依据。监测和减少空气污染（尤其是 PM2.5）暴露、提倡更健康的生活方式以及解决社会经济不平等问题对于预防和管理哮喘非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.20

自引率

2.20%

发文量

269

审稿时长

12 months

期刊介绍： The International Journal of Public Health publishes scientific articles relevant to global public health, from different countries and cultures, and assembles them into issues that raise awareness and understanding of public health problems and solutions. The Journal welcomes submissions of original research, critical and relevant reviews, methodological papers and manuscripts that emphasize theoretical content. IJPH sometimes publishes commentaries and opinions. Special issues highlight key areas of current research. The Editorial Board''s mission is to provide a thoughtful forum for contemporary issues and challenges in global public health research and practice.