Pericardiotomy as a novel treatment for heart failure with preserved ejection fraction.

IF 4.5 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Failure Reviews Pub Date : 2024-10-08 DOI:10.1007/s10741-024-10451-5

Shunichi Doi, Barry A Borlaug

引用次数: 0

Abstract

The pericardium plays an important role in modulating cardiac performance and hemodynamics in patients with heart failure with preserved ejection fraction (HFpEF). Pericardial constraint increases filling pressures in patients with HFpEF, particularly those with the obesity phenotype, atrial myopathy, right ventricular dysfunction, and tricuspid regurgitation. Preclinical and early stage clinical studies indicate that pericardiotomy may become a novel treatment for HFpEF. This review summarizes and discusses the pathophysiology of pericardial restraint and the possibility of pericardiotomy in HFpEF.

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心包切开术是治疗射血分数保留型心力衰竭的一种新方法。

心包在调节射血分数保留型心力衰竭（HFpEF）患者的心脏性能和血液动力学方面发挥着重要作用。心包约束会增加射血分数保留型心衰患者的充盈压，尤其是肥胖表型、心房肌病、右室功能障碍和三尖瓣反流患者。临床前和早期临床研究表明，心包切开术可能成为治疗高频心衰的一种新方法。本综述总结并讨论了心包束缚的病理生理学以及心包切开术治疗 HFpEF 的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart Failure Reviews 医学-心血管系统

CiteScore

10.40

自引率

2.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader''s knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.