Mitochondria at the crossroad of dysregulated inflammatory and metabolic processes in bipolar disorders

IF 8.8 2区 医学 Q1 IMMUNOLOGY
Jérémy Bernard , Ryad Tamouza , Ophélia Godin , Michael Berk , Ana C. Andreazza , Marion Leboyer
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引用次数: 0

Abstract

In last few decades, considerable evidence has emphasized the significant involvement of mitochondria, often referred to as the “powerhouse of the cell,” in the pathophysiology of bipolar disorder (BD). Given crucial mitochondrial functions in cellular metabolism and inflammation, both of which are compromised in BD, this perspective review examines the central role of mitochondria in inflammation and metabolism within the context of this disorder. We first describe the significance of mitochondria in metabolism before presenting the dysregulated inflammatory and metabolic processes. Then, we present a synthetic and hypothetical model of the importance of mitochondria in those dysfunctional pathways. The article also reviews different techniques for assessing mitochondrial function and discuss diagnostic and therapeutic implications. This review aims to improve the understanding of the inflammatory and metabolic comorbidities associated with bipolar disorders along with mitochondrial alterations within this context.
线粒体是双相情感障碍中炎症和代谢过程失调的交叉点。
在过去的几十年中,大量证据强调了线粒体(通常被称为 "细胞的动力室")在双相情感障碍(BD)病理生理学中的重要作用。鉴于线粒体在细胞新陈代谢和炎症中的重要功能在躁狂症中均受到损害,本视角综述探讨了线粒体在躁狂症的炎症和新陈代谢中的核心作用。我们首先描述了线粒体在新陈代谢中的重要作用,然后介绍了失调的炎症和新陈代谢过程。然后,我们就线粒体在这些功能失调途径中的重要性提出了一个合成的假设模型。文章还回顾了评估线粒体功能的不同技术,并讨论了诊断和治疗意义。这篇综述旨在加深人们对与双相情感障碍相关的炎症和代谢合并症以及线粒体改变的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
29.60
自引率
2.00%
发文量
290
审稿时长
28 days
期刊介绍: Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.
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